5XRA
Crystal structure of the human CB1 in complex with agonist AM11542
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1 | polymer | 438 | 48627.6 | 1 | UniProt (P21554) UniProt (P00323) Pfam (PF00001) Pfam (PF00258) | Homo sapiens (Human) | CB1,CANN6,CB1,CANN6 |
| 2 | B (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 3 | C (A) | (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | non-polymer | 449.5 | 1 | Chemie (8D3) | |||
| 4 | D, E (A) | OLEIC ACID | non-polymer | 282.5 | 2 | Chemie (OLA) | |||
| 5 | F, G (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) | |||
| 6 | H (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | I (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 99 - 306 (UniProt: P21554)
A: 1003 - 1148 (UniProt: P00323)
A: null - 414 (UniProt: P21554)
| PDB | External Database | Details |
|---|---|---|
| Ala 210 | Thr 210 | engineered mutation |
| Lys 273 | Glu 273 | engineered mutation |
| Val 283 | Thr 283 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1098 | Tyr 98 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 1002 | - | linker |
| Glu 340 | Arg 340 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48627.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2676.6 | |
| All* | Total formula weight | 51304.2 |
