5XRA
Crystal structure of the human CB1 in complex with agonist AM11542
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004949 | molecular_function | cannabinoid receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00201 |
| Number of Residues | 17 |
| Details | FLAVODOXIN Flavodoxin signature. IVYgSTtGnTEytAEtI |
| Chain | Residue | Details |
| A | ILE1006-ILE1022 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | LEU117-LEU142 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | HIS143-HIS154 | |
| A | ASP213-LYS232 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | PHE155-ILE175 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 39 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | ASP176-ASN187 | |
| A | ASN256-LYS273 | |
| A | ASP366-THR377 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | VAL188-ILE212 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | ALA233-TRP255 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | THR274-TRP299 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | LEU345-TYR365 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727 |
| Chain | Residue | Details |
| A | VAL378-LEU399 |
