5XQ2
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | TtAgo (D546N) | polymer | 685 | 76727.8 | 2 | UniProt (Q746M7) Pfam (PF22472) Pfam (PF18309) Pfam (PF22474) In PDB | Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) | Uncharacterized protein |
| 2 | X, E | DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3') | polymer | 22 | 6901.5 | 2 | Thermus thermophilus | ||
| 3 | Y, F | DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3') | polymer | 19 | 5708.7 | 2 | Thermus thermophilus | ||
| 4 | C, D | DNA (5'-D(*AP*GP*T)-3') | polymer | 3 | 901.6 | 2 | Thermus thermophilus | ||
| 5 | X, E | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 685 (UniProt: Q746M7)
| PDB | External Database | Details |
|---|---|---|
| Asn 546 | Asp 546 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 180479.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 48.6 | |
| All* | Total formula weight | 180527.8 |
