5XQ2
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0006260 | biological_process | DNA replication |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0006260 | biological_process | DNA replication |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0044355 | biological_process | clearance of foreign intracellular DNA |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue MG X 101 |
| Chain | Residue |
| X | DG4 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue MG E 101 |
| Chain | Residue |
| E | DG4 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide MET B 322 and VAL B 463 |
| Chain | Residue |
| B | LYS320 |
| B | LEU321 |
| B | GLY323 |
| B | GLN461 |
| B | VAL462 |
| B | ALA464 |
| B | SER466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 |
| Chain | Residue | Details |
| A | ASP478 | |
| A | ASN546 | |
| A | ASP660 | |
| B | ASP478 | |
| B | ASN546 | |
| B | ASP660 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 |
| Chain | Residue | Details |
| A | GLU512 | |
| B | GLU512 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 |
| Chain | Residue | Details |
| A | ASP478 | |
| B | ASP478 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 |
| Chain | Residue | Details |
| A | ASN546 | |
| A | ASP660 | |
| B | ASN546 | |
| B | ASP660 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 |
| Chain | Residue | Details |
| A | VAL685 | |
| B | VAL685 |
