5XOJ
Crystal structure of Xpo1p-PKI-Nup42p-Gsp1p-GTP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | GTP-binding nuclear protein | polymer | 182 | 20672.9 | 1 | UniProt (E7KFU1) In PDB | Saccharomyces cerevisiae (strain AWRI796) (Baker's yeast) | Gsp1p |
| 2 | C | Exportin-1 | polymer | 1047 | 120270.1 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Chromosome region maintenance protein 1,Karyopherin-124 |
| 3 | D | cAMP-dependent protein kinase inhibitor alpha | polymer | 76 | 8022.6 | 1 | UniProt (P61925) Pfam (PF02827) In PDB | Homo sapiens (Human) | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 4 | E, F, G | Nup42p | polymer | 35 | 3326.6 | 3 | UniProt (E7Q297) In PDB | Saccharomyces cerevisiae (strain FostersB) | |
| 5 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | water | water | 18.0 | 494 | Chemie (HOH) |
Sequence modifications
A: 1 - 182 (UniProt: E7KFU1)
C: 1 - 1084 (UniProt: P30822)
D: 1 - 76 (UniProt: P61925)
| PDB | External Database | Details |
|---|---|---|
| Leu 71 | Gln 71 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| - | Val 377 | deletion |
| - | Gln 378 | deletion |
| - | Arg 379 | deletion |
| - | Leu 380 | deletion |
| - | Pro 381 | deletion |
| - | Ala 382 | deletion |
| - | Thr 383 | deletion |
| - | Glu 384 | deletion |
| - | Met 385 | deletion |
| - | Ser 386 | deletion |
| - | Pro 387 | deletion |
| - | Leu 388 | deletion |
| - | Ile 389 | deletion |
| - | Gln 390 | deletion |
| - | Leu 391 | deletion |
| - | Ser 392 | deletion |
| - | Val 393 | deletion |
| - | Gly 394 | deletion |
| - | Ser 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| - | Ile 398 | deletion |
| - | Ser 399 | deletion |
| - | Thr 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Gly 403 | deletion |
| - | Ala 404 | deletion |
| - | Leu 405 | deletion |
| - | Asn 406 | deletion |
| - | Pro 407 | deletion |
| - | Glu 408 | deletion |
| - | Tyr 409 | deletion |
| - | Met 410 | deletion |
| - | Lys 411 | deletion |
| - | Arg 412 | deletion |
| - | Phe 413 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Leu 35 | Ser 35 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158945.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.5 | |
| All* | Total formula weight | 159492.8 |
