5XKM
Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 345 | 40232.1 | 6 | UniProt (O00408) Pfam (PF00233) | Homo sapiens (Human) | Cyclic GMP-stimulated phosphodiesterase,cGSPDE |
| 2 | G, I, K, N, Q... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 3 | H, L, O, R, V... (A, B, C, D, E...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | J, M, P, T, W... (A, B, C, D, E...) | 6-methyl-N-[(1R)-1-[4-(trifluoromethyloxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 378.3 | 6 | Chemie (87R) | |||
| 5 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 795 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 578 - 919 (UniProt: O00408)
| PDB | External Database | Details |
|---|---|---|
| Gly 575 | - | expression tag |
| His 576 | - | expression tag |
| Ala 577 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 241392.3 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2857.0 | |
| All* | Total formula weight | 244249.3 |
