5X7E
Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D3 dihydroxylase | polymer | 412 | 44991.7 | 1 | UniProt (P18326) | Streptomyces griseolus | CYP105A1,Cytochrome P450-CVA1,Cytochrome P450-SU1,Vitamin D3 hydroxylase,VD3 hydroxylase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5,6-dimethyl-6-oxidanyl-hept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydr o-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol | non-polymer | 428.6 | 1 | Chemie (7ZU) PubChem (44298812) PubChem (53486188) PubChem (54545809) PubChem (54545810) PubChem (54545811) PubChem (60204123) PubChem (70699390) PubChem (71312250) PubChem (71463883) PubChem (73946280) PubChem (86333217) PubChem (87086023) PubChem (87089291) PubChem (87663874) PubChem (88694968) PubChem (88702313) PubChem (92853215) PubChem (101477117) PubChem (101477120) PubChem (101617367) PubChem (118524614) PubChem (122172546) PubChem (122172900) PubChem (123812576) PubChem (124226491) PubChem (124226492) PubChem (124226494) PubChem (124427301) PubChem (125033111) PubChem (125033112) PubChem (125033113) PubChem (129606968) PubChem (131675017) PubChem (131954614) PubChem (134715546) PubChem (138113615) PubChem (144001784) PubChem (154810089) PubChem (162845354) PubChem (165430303) PubChem (171153530) PubChem (171320125) PubChem (171397565) PubChem (172041247) PubChem (172873912) PubChem (172897941) PubChem (173610692) PubChem (176520109) PubChem (177625691) PubChem (54545812) PubChem (86315559) PubChem (87663194) PubChem (88364016) PubChem (88694239) PubChem (88979275) PubChem (4525693) PubChem (92132756) PubChem (102585002) PubChem (6437855) PubChem (124226493) PubChem (9547248) PubChem (11690486) PubChem (141928102) PubChem (9547236) PubChem (9547243) PubChem (9547244) PubChem (9547245) PubChem (9547246) PubChem (9547247) PubChem (9547249) PubChem (9547250) PubChem (10202864) PubChem (10320404) PubChem (11510212) PubChem (13080230) PubChem (13080242) | |||
| 4 | D (A) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A: 1 - 406 (UniProt: P18326)
| PDB | External Database | Details |
|---|---|---|
| Ala 84 | Arg 84 | engineered mutation |
| Gln 308 | His 308 | variant |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44991.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1045.1 | |
| All* | Total formula weight | 46036.9 |
