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5X7E

Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D2

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005737cellular_componentcytoplasm
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016709molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
A0020037molecular_functionheme binding
A0046872molecular_functionmetal ion binding
A0070640biological_processvitamin D3 metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue HEM A 501
ChainResidue
APHE95
AARG297
AALA347
APHE348
AGLY349
AVAL352
AHIS353
ACYS355
AGLY357
AALA361
AHOH647
AILE96
AHOH666
AHOH693
AHIS103
AARG107
ALEU241
AALA244
ATHR248
ATHR249
AALA294

site_idAC2
Number of Residues10
Detailsbinding site for residue 7ZU A 502
ChainResidue
APRO79
ATHR81
AVAL88
APRO92
AARG193
AILE243
AILE293
AGLY296
AHOH649
AHOH770

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGVHQCLG
ChainResidueDetails
APHE348-GLY357

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18937506
ChainResidueDetails
ATHR81

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:18314962
ChainResidueDetails
AHIS103
AARG107
ASER236
AARG297
AHIS353

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:18314962, ECO:0000269|PubMed:18937506
ChainResidueDetails
AARG193
AILE293

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:18314962
ChainResidueDetails
ACYS355

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PDB entries from 2024-07-10

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