5X2C
Crystal structure of EGFR 696-1022 T790M/V948R in complex with SKLB(5)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D, E, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 3 | F, N (A, B) | 9-cyclopentyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-purine-2,8-diamine | non-polymer | 468.6 | 2 | Chemie (7XR) | |||
| 4 | O (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | P, Q (A, B) | water | water | 18.0 | 526 | Chemie (HOH) |
Sequence modifications
A, B: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Thr 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75449.2 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1593.3 | |
| All* | Total formula weight | 77042.5 |
