5WX1

The closed-conformation crystal structure of the full-length pestivirus NS3 with its NS4A protease cofactor segment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine protease NS3	polymer	733	81537.0	1	UniProt (Q5U8X5)	Classical swine fever virus	Non-structural protein 3
2	B (A)	water	water		18.0	226	Chemie (HOH)

Sequence modifications

A: 1 - 683 (UniProt: Q5U8X5)

PDB	External Database	Details
Met -49	-	expression tag
Ser -48	-	expression tag
His -47	-	expression tag
His -46	-	expression tag
His -45	-	expression tag
His -44	-	expression tag
His -43	-	expression tag
His -42	-	expression tag
His -41	-	expression tag
Ser -40	-	expression tag
Lys -39	-	expression tag
Arg -38	-	expression tag
His -37	-	expression tag
Ile -36	-	expression tag
Pro -35	-	expression tag
Val -34	-	expression tag
Val -33	-	expression tag
Thr -32	-	expression tag
Asp -31	-	expression tag
Ile -30	-	expression tag
Tyr -29	-	expression tag
Ser -28	-	expression tag
Ile -27	-	expression tag
Glu -26	-	expression tag
Asp -25	-	expression tag
His -24	-	expression tag
Arg -23	-	expression tag
Leu -22	-	expression tag
Glu -21	-	expression tag
Asp -20	-	expression tag
Thr -19	-	expression tag
Thr -18	-	expression tag
His -17	-	expression tag
Leu -16	-	expression tag
Gln -15	-	expression tag
Tyr -14	-	expression tag
Ala -13	-	expression tag
Pro -12	-	expression tag
Asn -11	-	expression tag
Ala -10	-	expression tag
Ile -9	-	expression tag
Lys -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Gly -5	-	expression tag
Lys -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 163	Ser 1752	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	81537.0
All*	Total formula weight	81537.0

*Water molecules are not included.