5WVO
Crystal structure of DNMT1 RFTS domain in complex with K18/K23 mono-ubiquitylated histone H3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ubiquitin | polymer | 76 | 8622.9 | 2 | UniProt (P62979) Pfam (PF00240) | Homo sapiens (Human) | |
| 2 | C (C) | DNA (cytosine-5)-methyltransferase 1 | polymer | 250 | 27980.3 | 1 | UniProt (P26358) Pfam (PF12047) | Homo sapiens (Human) | Dnmt1,CXXC-type zinc finger protein 9,DNA methyltransferase HsaI,M.HsaI,MCMT |
| 3 | D (D) | Histone H3.1 | polymer | 37 | 3824.5 | 1 | UniProt (P68431) | Homo sapiens (Human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 4 | E (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 76 (UniProt: P62979)
D: 1 - 36 (UniProt: P68431)
| PDB | External Database | Details |
|---|---|---|
| Cys 76 | Gly 76 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 18 | Lys 19 | engineered mutation |
| Cys 23 | Lys 24 | engineered mutation |
| Trp 37 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 49050.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 49116.1 |
