5WNJ
Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with lestaurtinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Receptor-interacting serine/threonine-protein kinase 4 | polymer | 342 | 38988.0 | 1 | UniProt (Q9ERK0) Pfam (PF00069) | Mus musculus (Mouse) | Ankyrin repeat domain-containing protein 3,PKC-associated protein kinase,PKC-regulated protein kinase |
| 2 | B (A) | Lestaurtinib | non-polymer | 439.5 | 1 | Chemie (2V9) PubChem (126565) PubChem (56846346) PubChem (59476505) PubChem (59922033) PubChem (70810196) PubChem (71717270) PubChem (73952981) PubChem (98405361) PubChem (9867822) PubChem (9867823) PubChem (9932888) PubChem (11419279) PubChem (14096316) PubChem (14096317) PubChem (172873885) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 4 | D (A) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 1 - 342 (UniProt: Q9ERK0)
| PDB | External Database | Details |
|---|---|---|
| Asn 143 | Asp 143 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38988.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 474.9 | |
| All* | Total formula weight | 39463.0 |
