5WNJ

Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with lestaurtinib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 2V9 A 401

Chain	Residue
A	VAL28
A	LEU150
A	SER160
A	GLY29
A	ALA49
A	LEU82
A	GLU97
A	TYR98
A	MET99
A	GLY102
A	ALA147

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 402

Chain	Residue
A	ARG251
A	ARG253
A	ALA254

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGGFGQVYkVrhvhwktw..........LAIK

Chain	Residue	Details
A	VAL28-LYS51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASN143

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LYS51
A	VAL28

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage => ECO:0000269|PubMed:12446564

Chain	Residue	Details
A	ASP342

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P57078

Chain	Residue	Details
A	LYS145
A	LYS51

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