5WIJ
JAK2 Pseudokinase in complex with NU6140
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK2 | polymer | 277 | 31681.4 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | A | 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide | non-polymer | 422.5 | 1 | Chemie (AQG) | |||
| 3 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 536 - 812 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 659 | Trp 659 | engineered mutation |
| Ala 777 | Trp 777 | engineered mutation |
| His 794 | Phe 794 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31681.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 422.5 | |
| All* | Total formula weight | 32103.9 |
