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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5WIE

Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, GVoltage-gated potassium channel subunit beta-2polymer33337353.12UniProt (P62483)
Pfam (PF00248)
In PDB		Rattus norvegicus (Rat)K(+) channel subunit beta-2,Kv-beta-2
2B, HPotassium voltage-gated channel subfamily A member 2,Potassium voltage-gated channel subfamily A member 2polymer53260455.32UniProt (P63142)
UniProt (P63141)
Pfam (PF02214)
Pfam (PF00520)
Pfam (PF07885)
In PDB		Rattus norvegicus (Rat)RAK,RBK2,RCK5,Voltage-gated potassium channel subunit Kv1.2,MK2,Voltage-gated potassium channel subunit Kv1.2
3A, GNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.42Chemie (NAP)
4B, H(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoatenon-polymer749.06Chemie (PGW)
5B, HPOTASSIUM IONnon-polymer39.18Chemie (K)
Sequence modifications
A, G: 36 - 367 (UniProt: P62483)
PDBExternal DatabaseDetails
Met 35-initiating methionine
B, H: 1 - 42 (UniProt: P63142)
PDBExternal DatabaseDetails
Met -36-initiating methionine
Ser -35-expression tag
Ala -34-expression tag
Trp -33-expression tag
Ser -32-expression tag
His -31-expression tag
Pro -30-expression tag
Gln -29-expression tag
Phe -28-expression tag
Glu -27-expression tag
Lys -26-expression tag
Gly -25-expression tag
Gly -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
Gly -21-expression tag
Gly -20-expression tag
Gly -19-expression tag
Ser -18-expression tag
Gly -17-expression tag
Gly -16-expression tag
Ser -15-expression tag
Ala -14-expression tag
Trp -13-expression tag
Ser -12-expression tag
His -11-expression tag
Pro -10-expression tag
Gln -9-expression tag
Phe -8-expression tag
Glu -7-expression tag
Lys -6-expression tag
Leu -5-expression tag
Val -4-expression tag
Pro -3-expression tag
Arg -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
His 15Leu 15linker
Ser 31Cys 31linker
Ser 32Cys 32linker
Gln 207Asn 207linker
Tyr 266-linker
Tyr 267-linker
Val 268-linker
Thr 269-linker
Ile 270-linker
Phe 271-linker
Leu 272-linker
Thr 273-linker
Glu 274-linker
Ser 275-linker
B, H: 43 - 56 (UniProt: P63141)
PDBExternal DatabaseDetails
Asn 276Asp 280conflict
Lys 277Ala 281conflict
Ser 278Gln 282conflict
Val 279Gln 283conflict
Leu 280Gly 284conflict
Phe 282Gln 286conflict
Gln 283Ala 287conflict
Asn 284Met 288conflict
Val 285Ser 289conflict
Arg 286Leu 290conflict
Arg 287Ala 291conflict
Val 288Ile 292conflict
Val 289Leu 293conflict
Gln 290Arg 294conflict
Ile 291Val 295conflict
Phe 292Ile 296conflict
Ile 294Leu 298conflict
Met 295Val 299conflict
Ile 297Val 301conflict
Leu 298Phe 302conflict
Trp 406Val 410engineered mutation
Ser 431Cys 435conflict
Ser 478Cys 482conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight195616.8
Non-Polymers*Number of molecules16
Total formula weight6293.6
All*Total formula weight201910.4
*Water molecules are not included.

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PDB entries from 2024-09-04

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