5WIE

Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0014069	cellular_component	postsynaptic density
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030424	cellular_component	axon
A	0034705	cellular_component	potassium channel complex
A	0043005	cellular_component	neuron projection
A	0043194	cellular_component	axon initial segment
A	0043679	cellular_component	axon terminus
A	0044224	cellular_component	juxtaparanode region of axon
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0045445	biological_process	myoblast differentiation
A	0050905	biological_process	neuromuscular process
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990031	cellular_component	pinceau fiber
A	2000008	biological_process	regulation of protein localization to cell surface
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
G	0002244	biological_process	hematopoietic progenitor cell differentiation
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0014069	cellular_component	postsynaptic density
G	0015459	molecular_function	potassium channel regulator activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0030424	cellular_component	axon
G	0034705	cellular_component	potassium channel complex
G	0043005	cellular_component	neuron projection
G	0043194	cellular_component	axon initial segment
G	0043679	cellular_component	axon terminus
G	0044224	cellular_component	juxtaparanode region of axon
G	0044325	molecular_function	transmembrane transporter binding
G	0044877	molecular_function	protein-containing complex binding
G	0045202	cellular_component	synapse
G	0045445	biological_process	myoblast differentiation
G	0050905	biological_process	neuromuscular process
G	0055085	biological_process	transmembrane transport
G	0071805	biological_process	potassium ion transmembrane transport
G	0098839	cellular_component	postsynaptic density membrane
G	0098978	cellular_component	glutamatergic synapse
G	1901379	biological_process	regulation of potassium ion transmembrane transport
G	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
G	1990031	cellular_component	pinceau fiber
G	2000008	biological_process	regulation of protein localization to cell surface
H	0005216	molecular_function	monoatomic ion channel activity
H	0005249	molecular_function	voltage-gated potassium channel activity
H	0006811	biological_process	monoatomic ion transport
H	0006813	biological_process	potassium ion transport
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0016020	cellular_component	membrane
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue NAP A 1001

Chain	Residue
A	GLY55
A	ARG189
A	GLN214
A	TRP243
A	SER244
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	GLY249
A	LYS254
A	THR56
A	SER263
A	ARG264
A	LEU321
A	GLY323
A	SER325
A	GLN329
A	GLU332
A	ASN333
A	TRP57
A	GLN63
A	ASP85
A	TYR90
A	LYS118
A	ASN158
A	SER188

---

site_id	AC2
Number of Residues	8
Details	binding site for residue PGW B 501

Chain	Residue
B	PRO358
B	ASP359
B	PHE361
B	TRP362
B	ILE381
B	LYS384
B	ILE385
B	SER388

---

site_id	AC3
Number of Residues	1
Details	binding site for residue PGW B 502

Chain	Residue
B	ILE294

---

site_id	AC4
Number of Residues	1
Details	binding site for residue PGW B 503

Chain	Residue
B	GLY382

---

site_id	AC5
Number of Residues	2
Details	binding site for residue PGW B 504

Chain	Residue
B	LEU313
B	THR397

---

site_id	AC6
Number of Residues	2
Details	binding site for residue PGW B 505

Chain	Residue
B	GLN214
B	GLU274

---

site_id	AC7
Number of Residues	12
Details	binding site for residue K B 506

Chain	Residue
B	VAL371
B	VAL371
B	VAL371
B	VAL371
B	GLY372
B	GLY372
B	GLY372
B	GLY372
B	K507
B	K507
B	K507
B	K507

---

site_id	AC8
Number of Residues	16
Details	binding site for residue K B 507

Chain	Residue
B	THR370
B	THR370
B	THR370
B	THR370
B	VAL371
B	VAL371
B	VAL371
B	VAL371
B	K506
B	K506
B	K506
B	K506
B	K508
B	K508
B	K508
B	K508

---

site_id	AC9
Number of Residues	8
Details	binding site for residue K B 508

Chain	Residue
B	THR370
B	THR370
B	THR370
B	THR370
B	K507
B	K507
B	K507
B	K507

---

site_id	AD1
Number of Residues	30
Details	binding site for residue NAP G 1001

Chain	Residue
G	LEU321
G	LEU322
G	GLY323
G	ALA324
G	SER325
G	GLN329
G	GLU332
G	ASN333
G	GLY55
G	THR56
G	TRP57
G	GLN63
G	ASP85
G	TYR90
G	ASN158
G	SER188
G	ARG189
G	GLN214
G	TRP243
G	SER244
G	PRO245
G	LEU246
G	ALA247
G	CYS248
G	GLY249
G	SER252
G	LYS254
G	TYR262
G	SER263
G	ARG264

---

site_id	AD2
Number of Residues	5
Details	binding site for residue PGW H 501

Chain	Residue
H	PRO358
H	ASP359
H	PHE361
H	TRP362
H	LYS384

---

site_id	AD3
Number of Residues	12
Details	binding site for residue K H 502

Chain	Residue
H	GLY372
H	GLY372
H	GLY372
H	GLY372
H	TYR373
H	TYR373
H	TYR373
H	TYR373
H	K503
H	K503
H	K503
H	K503

---

site_id	AD4
Number of Residues	12
Details	binding site for residue K H 503

Chain	Residue
H	VAL371
H	VAL371
H	VAL371
H	VAL371
H	GLY372
H	GLY372
H	GLY372
H	GLY372
H	K502
H	K502
H	K502
H	K502

---

site_id	AD5
Number of Residues	12
Details	binding site for residue K H 504

Chain	Residue
H	THR370
H	THR370
H	THR370
H	THR370
H	VAL371
H	VAL371
H	VAL371
H	VAL371
H	K505
H	K505
H	K505
H	K505

---

site_id	AD6
Number of Residues	8
Details	binding site for residue K H 505

Chain	Residue
H	THR370
H	THR370
H	THR370
H	THR370
H	K504
H	K504
H	K504
H	K504

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18672894","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21357749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13303","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	38
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12151401","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	38
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	51
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	22
Details	Intramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	14
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	26
Details	Region: {"description":"S4-S5 linker","evidences":[{"source":"PubMed","id":"16002579","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	10
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Site: {"description":"Important for normal, slow channel gating","evidences":[{"source":"PubMed","id":"17766348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Site: {"description":"Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin","evidences":[{"source":"PubMed","id":"25514171","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16770729","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---