5WHR
Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Indoleamine 2,3-dioxygenase 1 | polymer | 393 | 44167.8 | 2 | UniProt (P14902) Pfam (PF01231) | Homo sapiens (Human) | IDO-1,Indoleamine-pyrrole 2,3-dioxygenase |
| 2 | C, E (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, F (A, B) | (3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione | non-polymer | 232.2 | 2 | Chemie (AOJ) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A, B: 12 - 403 (UniProt: P14902)
| PDB | External Database | Details |
|---|---|---|
| Gly 11 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 88335.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1697.4 | |
| All* | Total formula weight | 90033.0 |
