5WGQ
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-BCP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 261 | 29774.1 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (E, F) | SRC2-BCP1 | polymer | 13 | 1387.7 | 2 | UniProt (by SIFTS) (Q15596) BIRD (PRD_002318) | synthetic construct | |
| 3 | E, F (A, B) | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) PubChem (1807201) PubChem (450) PubChem (5757) PubChem (5998) PubChem (10596) PubChem (14880) PubChem (68570) PubChem (667480) PubChem (667515) PubChem (721867) PubChem (928284) PubChem (1258565) PubChem (5317221) PubChem (5745505) PubChem (6328313) PubChem (6432565) PubChem (6560352) PubChem (6603846) PubChem (6918968) PubChem (6919041) PubChem (7000012) PubChem (7004689) PubChem (7048584) PubChem (7048670) PubChem (7061189) PubChem (7067800) PubChem (9795489) PubChem (9811784) PubChem (9903595) PubChem (9938293) PubChem (11869602) PubChem (11870431) PubChem (12313787) PubChem (12313791) PubChem (12313794) PubChem (16757676) PubChem (43912931) PubChem (44284023) PubChem (177015577) PubChem (46781508) PubChem (1807200) PubChem (5317222) PubChem (54403267) PubChem (56624791) PubChem (57041922) PubChem (12313788) PubChem (58650893) PubChem (59084698) PubChem (162947701) PubChem (166849971) PubChem (68014581) PubChem (68209947) PubChem (70220248) PubChem (70864205) PubChem (91740223) PubChem (101691329) PubChem (118548795) PubChem (126969992) PubChem (129010410) PubChem (129317336) PubChem (130307439) PubChem (130307440) PubChem (143489158) PubChem (144605119) PubChem (145157829) PubChem (145610824) PubChem (154109755) PubChem (172873304) | |||
| 4 | G, H, I (A, B, F) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A, B: 297 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 294 | - | initiating methionine |
| Asp 295 | - | expression tag |
| Pro 296 | - | expression tag |
| Ser 537 | Tyr 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62323.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.8 | |
| All* | Total formula weight | 62868.4 |
