5WGL
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ricolinostat (ACY-1215)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hdac6 protein | polymer | 364 | 40285.5 | 2 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (Zebrafish) | histone deacetylase 6 |
| 2 | C, P (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, Q, R (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | F, S (A, B) | 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide | non-polymer | 433.5 | 2 | Chemie (AH4) | |||
| 5 | AA, BA, G, H, I... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 6 | N (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | O (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 8 | CA, DA (A, B) | water | water | 18.0 | 549 | Chemie (HOH) |
Sequence modifications
A, B: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80571.0 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 2442.5 | |
| All* | Total formula weight | 83013.5 |
