5WG3
Human GRK2 in complex with Gbetagamma subunits and CCG258748
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-adrenergic receptor kinase 1 | polymer | 689 | 79692.6 | 1 | UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB | Homo sapiens (Human) | Beta-ARK-1,G-protein coupled receptor kinase 2 |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62871) Pfam (PF00400) In PDB | Bos taurus (Bovine) | Transducin beta chain 1 |
| 3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (Bovine) | G gamma-I |
| 4 | A | 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl)oxy]methyl}piperidin-4-yl]-N-[(1H-pyrazol-3-yl)methyl]benzamide | non-polymer | 448.5 | 1 | Chemie (AFM) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
G: 1 - 71 (UniProt: P63212)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 124954.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 472.8 | |
| All* | Total formula weight | 125427.4 |
