5WEV
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK2 | polymer | 319 | 37375.3 | 1 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
2 | A | N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | non-polymer | 347.2 | 1 | Chemie (9ZS) | |||
3 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 833 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 814 | - | expression tag |
Gly 815 | - | expression tag |
Ser 816 | - | expression tag |
Ser 817 | - | expression tag |
His 818 | - | expression tag |
His 819 | - | expression tag |
His 820 | - | expression tag |
His 821 | - | expression tag |
His 822 | - | expression tag |
His 823 | - | expression tag |
Ser 824 | - | expression tag |
Ser 825 | - | expression tag |
Gly 826 | - | expression tag |
Leu 827 | - | expression tag |
Val 828 | - | expression tag |
Pro 829 | - | expression tag |
Arg 830 | - | expression tag |
Gly 831 | - | expression tag |
Ser 832 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37375.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 347.2 | |
All* | Total formula weight | 37722.5 |