5WDX

Structure of NS3 from HCV strain JFH-1 that is an unusually robust helicase that is primed to bind and unwind viral RNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	JFH-1 NS3	polymer	649	68842.2	1	UniProt (R9TEU1) Pfam (PF02907) Pfam (PF07652) Pfam (PF22027)	Hepatitis C virus	Genome polyprotein
2	B (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	C, D (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E (A)	water	water		18.0	63	Chemie (HOH)

Sequence modifications

A: 1 - 631 (UniProt: R9TEU1)

PDB	External Database	Details
Gly -15	-	expression tag
Cys -14	-	expression tag
Val -13	-	expression tag
Ser -12	-	expression tag
Ile -11	-	expression tag
Ile -10	-	expression tag
Gly -9	-	expression tag
Arg -8	-	expression tag
Leu -7	-	expression tag
His -6	-	expression tag
Val -5	-	expression tag
Asn -4	-	expression tag
Gln -3	-	expression tag
Arg -2	-	expression tag
Gly -2	-	expression tag
Ser -2	-	expression tag
Gly -2	-	expression tag
Ser -2	-	expression tag
Ser 2	Pro 1032	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68842.2
Non-Polymers*	Number of molecules	3
	Total formula weight	114.0
All*	Total formula weight	68956.2

*Water molecules are not included.