5WBX
Structural insights into the potency of SK/IK channel positive modulators
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Small conductance calcium-activated potassium channel protein 2 | polymer | 95 | 11240.3 | 1 | UniProt (Q9H2S1) Pfam (PF02888) | Homo sapiens (Human) | SKCa2,KCa2.2 |
| 2 | B (R) | Calmodulin-1 | polymer | 146 | 16420.0 | 1 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (Human) | |
| 3 | C, D, E, F (B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, K (B, R) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | H, I (R) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | J (R) | (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one | non-polymer | 255.1 | 1 | Chemie (AJY) | |||
| 7 | L, M (B, R) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
B: 396 - 487 (UniProt: Q9H2S1)
R: 4 - 147 (UniProt: P0DP23)
| PDB | External Database | Details |
|---|---|---|
| Gly 395 | - | expression tag |
| Ala 409 | Asn 408 | engineered mutation |
| Leu 488 | - | expression tag |
| Glu 489 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 2 | - | expression tag |
| Ala 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27660.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 903.7 | |
| All* | Total formula weight | 28564.0 |
