5WBX
Structural insights into the potency of SK/IK channel positive modulators
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SEALED TUBE |
Source details | BRUKER D8 QUEST |
Temperature [K] | 100 |
Detector technology | PIXEL |
Collection date | 2016-11-03 |
Detector | Bruker PHOTON II |
Wavelength(s) | 1.3148 |
Spacegroup name | C 1 2 1 |
Unit cell lengths | 77.328, 66.091, 65.435 |
Unit cell angles | 90.00, 93.84, 90.00 |
Refinement procedure
Resolution | 26.836 - 1.900 |
R-factor | 0.1907 |
Rwork | 0.188 |
R-free | 0.24280 |
Data reduction software | XPREP |
Data scaling software | XPREP |
Phasing software | PHASER |
Refinement software | REFMAC |
Data quality characteristics
Overall | |
Low resolution limit [Å] | 26.840 |
High resolution limit [Å] | 1.900 |
Number of reflections | 25882 |
<I/σ(I)> | 14.9 |
Completeness [%] | 98.4 |
Redundancy | 6.4 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, SITTING DROP | 5.8 | 293.15 | 0.1 M Sodium itrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Lithium sulfate monohydrate |