5WB2
US28 bound to engineered chemokine CX3CL1.35 and nanobodies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Envelope protein US28, nanobody 7 fusion protein | polymer | 460 | 52158.4 | 1 | UniProt (Q80KM9) Pfam (PF00001) UniProt (by SIFTS) (P69333) | Human cytomegalovirus (HHV-5) | US28 protein |
| 2 | B (B) | CX3CL1 protein | polymer | 76 | 8631.1 | 1 | UniProt (Q6I9S9) Pfam (PF00048) UniProt (by SIFTS) (P78423) | Homo sapiens (Human) | engineered chemokine CX3CL1.35 |
| 3 | C (D) | nanobody B1 | polymer | 131 | 14151.6 | 1 | synthetic construct | ||
| 4 | D, E (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 5 | F, G, H, I (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 4 | Chemie (OLC) | |||
| 6 | J (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | K (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) |
Sequence modifications
A: 1 - 982 (UniProt: Q80KM9)
A: 983 - 1125 (PDB: 5WB2)
B: 10 - 76 (UniProt: Q6I9S9)
| PDB | External Database | Details |
|---|---|---|
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Ala 0 | - | expression tag |
B: 10 - 76 (UniProt: Q6I9S9)
| PDB | External Database | Details |
|---|---|---|
| Leu 1 | - | expression tag |
| Leu 2 | - | expression tag |
| Pro 3 | - | expression tag |
| His 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Asn 6 | - | expression tag |
| Tyr 7 | - | expression tag |
| Cys 8 | - | expression tag |
| Ala 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 74941.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2460.1 | |
| All* | Total formula weight | 77401.2 |
