5W5Z
Crystal structure of BAXP168G in complex with an activating antibody at high resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | L | 3C10 Fab light chain | polymer | 213 | 23457.0 | 1 | Rattus norvegicus | ||
| 2 | H | 3C10 Fab heavy chain | polymer | 234 | 24917.0 | 1 | Rattus norvegicus | ||
| 3 | A | Apoptosis regulator BAX | polymer | 163 | 18158.8 | 1 | UniProt (Q07812) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 4,Bcl2-L-4 |
| 4 | L | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | L | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 6 | H | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 7 | H | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 8 | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 32 - 192 (UniProt: Q07812)
| PDB | External Database | Details |
|---|---|---|
| Ser 62 | Cys 62 | engineered mutation |
| Ser 126 | Cys 126 | engineered mutation |
| Gly 168 | Pro 168 | engineered mutation |
| Ser 193 | - | expression tag |
| Ser 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 66532.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1070.2 | |
| All* | Total formula weight | 67603.1 |
