5W2S
Crystal Structure of Mycobacterium Tuberculosis KasA in complex with KMG
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | polymer | 439 | 45788.6 | 1 | UniProt (H8ESN0) Pfam (PF00109) Pfam (PF02801) UniProt (by SIFTS) (P9WQD9) In PDB | Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) | Beta-ketoacyl-ACP synthase 1,KAS 1 |
2 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
3 | A | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | A | N-(3-methyl-2H-indazol-5-yl)butane-1-sulfonamide | non-polymer | 267.3 | 1 | Chemie (KMG) | |||
6 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 1 - 416 (UniProt: H8ESN0)
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Ser -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
Ser -12 | - | expression tag |
Ser -11 | - | expression tag |
Gly -10 | - | expression tag |
Leu -9 | - | expression tag |
Val -8 | - | expression tag |
Pro -7 | - | expression tag |
Arg -6 | - | expression tag |
Gly -5 | - | expression tag |
Ser -4 | - | expression tag |
His -3 | - | expression tag |
Met -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Val 1 | Met 1 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45788.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 534.6 | |
All* | Total formula weight | 46323.2 |