5W2A

Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dCMPNPP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	DNA polymerase kappa	polymer	551	63287.1	2	UniProt (Q9UBT6) Pfam (PF00817) Pfam (PF11798) Pfam (PF11799) In PDB	Homo sapiens (Human)	DINB protein,DINP
2	C, P	DNA (5'-D(P*GP*CP*GP*GP*AP*TP*CP*AP*G)-3')	polymer	9	2780.8	2		unidentified
3	D, T	DNA (5'-D(*AP*TP*GP*(LDG)P*CP*TP*GP*AP*TP*CP*CP*GP*C)-3')	polymer	13	4247.9	2		unidentified
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A, B, P	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	A, B	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine	non-polymer		466.2	2	Chemie (0KX)
7	A, B	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)
8		water	water		18.0	28	Chemie (HOH)

Sequence modifications

A, B: 1 - 526 (UniProt: Q9UBT6)

PDB	External Database	Details
Met -24	-	initiating methionine
Ser -23	-	expression tag
Tyr -22	-	expression tag
Tyr -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Asp -14	-	expression tag
Tyr -13	-	expression tag
Asp -12	-	expression tag
Ile -11	-	expression tag
Pro -10	-	expression tag
Thr -9	-	expression tag
Thr -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	140631.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1649.7
All*	Total formula weight	142281.2

*Water molecules are not included.