5W0W

Crystal structure of Protein Phosphatase 2A bound to TIPRL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	polymer	585	65701.6	4	UniProt (P30153) Pfam (PF02985)	Homo sapiens (Human)	Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha
2	B, E, H, K (B, E, H, K)	TIP41-like protein	polymer	251	29044.3	4	UniProt (Q8BH58) Pfam (PF04176)	Mus musculus (Mouse)
3	C, F, I, L (C, F, I, L)	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	polymer	311	35780.3	4	UniProt (P67775) Pfam (PF00149)	Homo sapiens (Human)	PP2A-alpha,Replication protein C,RP-C
4	M, N, O, P (C, F, I, L)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)

Sequence modifications

A, D, G, J: 9 - 589 (UniProt: P30153)

PDB	External Database	Details
Gly 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
Mse 8	-	expression tag

B, E, H, K: 12 - 259 (UniProt: Q8BH58)

PDB	External Database	Details
Gly 9	-	expression tag
Ser 10	-	expression tag
Met 11	-	expression tag

C, F, I, L: 1 - 309 (UniProt: P67775)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	522104.7
Non-Polymers*	Number of molecules	4
	Total formula weight	219.8
All*	Total formula weight	522324.4

*Water molecules are not included.