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5W0W

Crystal structure of Protein Phosphatase 2A bound to TIPRL

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0000775cellular_componentchromosome, centromeric region
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007059biological_processchromosome segregation
A0007143biological_processfemale meiotic nuclear division
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016328cellular_componentlateral plasma membrane
A0019888molecular_functionprotein phosphatase regulator activity
A0030425cellular_componentdendrite
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0040008biological_processregulation of growth
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0045202cellular_componentsynapse
A0045595biological_processregulation of cell differentiation
A0046982molecular_functionprotein heterodimerization activity
A0051232biological_processmeiotic spindle elongation
A0051306biological_processmitotic sister chromatid separation
A0051754biological_processmeiotic sister chromatid cohesion, centromeric
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0090443cellular_componentFAR/SIN/STRIPAK complex
A0098978cellular_componentglutamatergic synapse
A1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
A1990405molecular_functionprotein antigen binding
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000077biological_processDNA damage checkpoint signaling
B0003674molecular_functionmolecular_function
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0031929biological_processTOR signaling
B0043666biological_processregulation of phosphoprotein phosphatase activity
C0000159cellular_componentprotein phosphatase type 2A complex
C0000278biological_processmitotic cell cycle
C0000775cellular_componentchromosome, centromeric region
C0000922cellular_componentspindle pole
C0001932biological_processregulation of protein phosphorylation
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006470biological_processprotein dephosphorylation
C0007498biological_processmesoderm development
C0008287cellular_componentprotein serine/threonine phosphatase complex
C0010288biological_processresponse to lead ion
C0010719biological_processnegative regulation of epithelial to mesenchymal transition
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017018molecular_functionmyosin phosphatase activity
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035970biological_processpeptidyl-threonine dephosphorylation
C0040008biological_processregulation of growth
C0043029biological_processT cell homeostasis
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0045595biological_processregulation of cell differentiation
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0048156molecular_functiontau protein binding
C0050811molecular_functionGABA receptor binding
C0051321biological_processmeiotic cell cycle
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0070262biological_processpeptidyl-serine dephosphorylation
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090443cellular_componentFAR/SIN/STRIPAK complex
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1904526biological_processregulation of microtubule binding
C1904528biological_processpositive regulation of microtubule binding
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
D0000159cellular_componentprotein phosphatase type 2A complex
D0000775cellular_componentchromosome, centromeric region
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0007059biological_processchromosome segregation
D0007143biological_processfemale meiotic nuclear division
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0016328cellular_componentlateral plasma membrane
D0019888molecular_functionprotein phosphatase regulator activity
D0030425cellular_componentdendrite
D0035331biological_processnegative regulation of hippo signaling
D0035556biological_processintracellular signal transduction
D0040008biological_processregulation of growth
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043029biological_processT cell homeostasis
D0045202cellular_componentsynapse
D0045595biological_processregulation of cell differentiation
D0046982molecular_functionprotein heterodimerization activity
D0051232biological_processmeiotic spindle elongation
D0051306biological_processmitotic sister chromatid separation
D0051754biological_processmeiotic sister chromatid cohesion, centromeric
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0065003biological_processprotein-containing complex assembly
D0070062cellular_componentextracellular exosome
D0090443cellular_componentFAR/SIN/STRIPAK complex
D0098978cellular_componentglutamatergic synapse
D1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
D1990405molecular_functionprotein antigen binding
D2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
E0000077biological_processDNA damage checkpoint signaling
E0003674molecular_functionmolecular_function
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0031929biological_processTOR signaling
E0043666biological_processregulation of phosphoprotein phosphatase activity
F0000159cellular_componentprotein phosphatase type 2A complex
F0000278biological_processmitotic cell cycle
F0000775cellular_componentchromosome, centromeric region
F0000922cellular_componentspindle pole
F0001932biological_processregulation of protein phosphorylation
F0004721molecular_functionphosphoprotein phosphatase activity
F0004722molecular_functionprotein serine/threonine phosphatase activity
F0004725molecular_functionprotein tyrosine phosphatase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0006470biological_processprotein dephosphorylation
F0007498biological_processmesoderm development
F0008287cellular_componentprotein serine/threonine phosphatase complex
F0010288biological_processresponse to lead ion
F0010719biological_processnegative regulation of epithelial to mesenchymal transition
F0015630cellular_componentmicrotubule cytoskeleton
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0017018molecular_functionmyosin phosphatase activity
F0035331biological_processnegative regulation of hippo signaling
F0035556biological_processintracellular signal transduction
F0035970biological_processpeptidyl-threonine dephosphorylation
F0040008biological_processregulation of growth
F0043029biological_processT cell homeostasis
F0045121cellular_componentmembrane raft
F0045202cellular_componentsynapse
F0045595biological_processregulation of cell differentiation
F0046872molecular_functionmetal ion binding
F0046982molecular_functionprotein heterodimerization activity
F0048156molecular_functiontau protein binding
F0050811molecular_functionGABA receptor binding
F0051321biological_processmeiotic cell cycle
F0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0070062cellular_componentextracellular exosome
F0070262biological_processpeptidyl-serine dephosphorylation
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0090443cellular_componentFAR/SIN/STRIPAK complex
F1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
F1904526biological_processregulation of microtubule binding
F1904528biological_processpositive regulation of microtubule binding
F1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
F2000045biological_processregulation of G1/S transition of mitotic cell cycle
G0000159cellular_componentprotein phosphatase type 2A complex
G0000775cellular_componentchromosome, centromeric region
G0004722molecular_functionprotein serine/threonine phosphatase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005694cellular_componentchromosome
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0007059biological_processchromosome segregation
G0007143biological_processfemale meiotic nuclear division
G0015630cellular_componentmicrotubule cytoskeleton
G0016020cellular_componentmembrane
G0016328cellular_componentlateral plasma membrane
G0019888molecular_functionprotein phosphatase regulator activity
G0030425cellular_componentdendrite
G0035331biological_processnegative regulation of hippo signaling
G0035556biological_processintracellular signal transduction
G0040008biological_processregulation of growth
G0042995cellular_componentcell projection
G0043005cellular_componentneuron projection
G0043025cellular_componentneuronal cell body
G0043029biological_processT cell homeostasis
G0045202cellular_componentsynapse
G0045595biological_processregulation of cell differentiation
G0046982molecular_functionprotein heterodimerization activity
G0051232biological_processmeiotic spindle elongation
G0051306biological_processmitotic sister chromatid separation
G0051754biological_processmeiotic sister chromatid cohesion, centromeric
G0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
G0065003biological_processprotein-containing complex assembly
G0070062cellular_componentextracellular exosome
G0090443cellular_componentFAR/SIN/STRIPAK complex
G0098978cellular_componentglutamatergic synapse
G1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
G1990405molecular_functionprotein antigen binding
G2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
H0000077biological_processDNA damage checkpoint signaling
H0003674molecular_functionmolecular_function
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0031929biological_processTOR signaling
H0043666biological_processregulation of phosphoprotein phosphatase activity
I0000159cellular_componentprotein phosphatase type 2A complex
I0000278biological_processmitotic cell cycle
I0000775cellular_componentchromosome, centromeric region
I0000922cellular_componentspindle pole
I0001932biological_processregulation of protein phosphorylation
I0004721molecular_functionphosphoprotein phosphatase activity
I0004722molecular_functionprotein serine/threonine phosphatase activity
I0004725molecular_functionprotein tyrosine phosphatase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005694cellular_componentchromosome
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0006470biological_processprotein dephosphorylation
I0007498biological_processmesoderm development
I0008287cellular_componentprotein serine/threonine phosphatase complex
I0010288biological_processresponse to lead ion
I0010719biological_processnegative regulation of epithelial to mesenchymal transition
I0015630cellular_componentmicrotubule cytoskeleton
I0016020cellular_componentmembrane
I0016787molecular_functionhydrolase activity
I0017018molecular_functionmyosin phosphatase activity
I0035331biological_processnegative regulation of hippo signaling
I0035556biological_processintracellular signal transduction
I0035970biological_processpeptidyl-threonine dephosphorylation
I0040008biological_processregulation of growth
I0043029biological_processT cell homeostasis
I0045121cellular_componentmembrane raft
I0045202cellular_componentsynapse
I0045595biological_processregulation of cell differentiation
I0046872molecular_functionmetal ion binding
I0046982molecular_functionprotein heterodimerization activity
I0048156molecular_functiontau protein binding
I0050811molecular_functionGABA receptor binding
I0051321biological_processmeiotic cell cycle
I0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
I0070062cellular_componentextracellular exosome
I0070262biological_processpeptidyl-serine dephosphorylation
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0090443cellular_componentFAR/SIN/STRIPAK complex
I1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
I1904526biological_processregulation of microtubule binding
I1904528biological_processpositive regulation of microtubule binding
I1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
I2000045biological_processregulation of G1/S transition of mitotic cell cycle
J0000159cellular_componentprotein phosphatase type 2A complex
J0000775cellular_componentchromosome, centromeric region
J0004722molecular_functionprotein serine/threonine phosphatase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005694cellular_componentchromosome
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0007059biological_processchromosome segregation
J0007143biological_processfemale meiotic nuclear division
J0015630cellular_componentmicrotubule cytoskeleton
J0016020cellular_componentmembrane
J0016328cellular_componentlateral plasma membrane
J0019888molecular_functionprotein phosphatase regulator activity
J0030425cellular_componentdendrite
J0035331biological_processnegative regulation of hippo signaling
J0035556biological_processintracellular signal transduction
J0040008biological_processregulation of growth
J0042995cellular_componentcell projection
J0043005cellular_componentneuron projection
J0043025cellular_componentneuronal cell body
J0043029biological_processT cell homeostasis
J0045202cellular_componentsynapse
J0045595biological_processregulation of cell differentiation
J0046982molecular_functionprotein heterodimerization activity
J0051232biological_processmeiotic spindle elongation
J0051306biological_processmitotic sister chromatid separation
J0051754biological_processmeiotic sister chromatid cohesion, centromeric
J0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J0065003biological_processprotein-containing complex assembly
J0070062cellular_componentextracellular exosome
J0090443cellular_componentFAR/SIN/STRIPAK complex
J0098978cellular_componentglutamatergic synapse
J1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
J1990405molecular_functionprotein antigen binding
J2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
K0000077biological_processDNA damage checkpoint signaling
K0003674molecular_functionmolecular_function
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0031929biological_processTOR signaling
K0043666biological_processregulation of phosphoprotein phosphatase activity
L0000159cellular_componentprotein phosphatase type 2A complex
L0000278biological_processmitotic cell cycle
L0000775cellular_componentchromosome, centromeric region
L0000922cellular_componentspindle pole
L0001932biological_processregulation of protein phosphorylation
L0004721molecular_functionphosphoprotein phosphatase activity
L0004722molecular_functionprotein serine/threonine phosphatase activity
L0004725molecular_functionprotein tyrosine phosphatase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005694cellular_componentchromosome
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005886cellular_componentplasma membrane
L0006470biological_processprotein dephosphorylation
L0007498biological_processmesoderm development
L0008287cellular_componentprotein serine/threonine phosphatase complex
L0010288biological_processresponse to lead ion
L0010719biological_processnegative regulation of epithelial to mesenchymal transition
L0015630cellular_componentmicrotubule cytoskeleton
L0016020cellular_componentmembrane
L0016787molecular_functionhydrolase activity
L0017018molecular_functionmyosin phosphatase activity
L0035331biological_processnegative regulation of hippo signaling
L0035556biological_processintracellular signal transduction
L0035970biological_processpeptidyl-threonine dephosphorylation
L0040008biological_processregulation of growth
L0043029biological_processT cell homeostasis
L0045121cellular_componentmembrane raft
L0045202cellular_componentsynapse
L0045595biological_processregulation of cell differentiation
L0046872molecular_functionmetal ion binding
L0046982molecular_functionprotein heterodimerization activity
L0048156molecular_functiontau protein binding
L0050811molecular_functionGABA receptor binding
L0051321biological_processmeiotic cell cycle
L0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
L0070062cellular_componentextracellular exosome
L0070262biological_processpeptidyl-serine dephosphorylation
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0090443cellular_componentFAR/SIN/STRIPAK complex
L1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
L1904526biological_processregulation of microtubule binding
L1904528biological_processpositive regulation of microtubule binding
L1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
L2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue MN F 501
ChainResidue
FHIS118
FHIS241

site_idAC2
Number of Residues1
Detailsbinding site for residue MN I 501
ChainResidue
IHIS118

site_idAC3
Number of Residues1
Detailsbinding site for residue MN L 501
ChainResidue
LTYR265

site_idAC4
Number of Residues19
Detailsbinding site for Di-peptide ARG G 221 and ASP G 254
ChainResidue
GSER219
GVAL220
GLEU222
GLEU223
GALA224
GVAL225
GGLN250
GALA251
GALA252
GGLU253
GLYS255
GSER256
GVAL259
GARG260
GLEU212
GALA213
GASP215
GGLN217
GASP218

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
CLEU114-GLU119

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:P36873
ChainResidueDetails
CHIS118
FHIS118
IHIS118
LHIS118

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:17055435
ChainResidueDetails
FASP85
FASN117
FHIS167
FHIS241
IASP57
IHIS59
IASP85
IASN117
IHIS167
IHIS241
LASP57
LHIS59
LASP85
LASN117
LHIS167
LHIS241
CASP57
CHIS59
CASP85
CASN117
CHIS167
CHIS241
FASP57
FHIS59

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P67774
ChainResidueDetails
CTYR307
FTYR307
ITYR307
LTYR307

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Leucine methyl ester => ECO:0000269|PubMed:8206937
ChainResidueDetails
CLEU309
FLEU309
ILEU309
LLEU309

220472

PDB entries from 2024-05-29

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