5W0W

Crystal structure of Protein Phosphatase 2A bound to TIPRL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0007059	biological_process	chromosome segregation
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0016180	biological_process	snRNA processing
A	0016328	cellular_component	lateral plasma membrane
A	0019888	molecular_function	protein phosphatase regulator activity
A	0030425	cellular_component	dendrite
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0035330	biological_process	regulation of hippo signaling
A	0035331	biological_process	negative regulation of hippo signaling
A	0035556	biological_process	intracellular signal transduction
A	0040008	biological_process	regulation of growth
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043029	biological_process	T cell homeostasis
A	0045202	cellular_component	synapse
A	0045595	biological_process	regulation of cell differentiation
A	0046982	molecular_function	protein heterodimerization activity
A	0051225	biological_process	spindle assembly
A	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
A	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0065003	biological_process	protein-containing complex assembly
A	0070062	cellular_component	extracellular exosome
A	0090443	cellular_component	FAR/SIN/STRIPAK complex
A	0098978	cellular_component	glutamatergic synapse
A	0160232	cellular_component	INTAC complex
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
A	1990405	molecular_function	protein antigen binding
B	0000077	biological_process	DNA damage checkpoint signaling
B	0003674	molecular_function	molecular_function
B	0004864	molecular_function	protein phosphatase inhibitor activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0031929	biological_process	TOR signaling
B	0072542	molecular_function	protein phosphatase activator activity
C	0000159	cellular_component	protein phosphatase type 2A complex
C	0000278	biological_process	mitotic cell cycle
C	0000775	cellular_component	chromosome, centromeric region
C	0000785	cellular_component	chromatin
C	0000922	cellular_component	spindle pole
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0004725	molecular_function	protein tyrosine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006470	biological_process	protein dephosphorylation
C	0010288	biological_process	response to lead ion
C	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0016180	biological_process	snRNA processing
C	0016787	molecular_function	hydrolase activity
C	0031113	biological_process	regulation of microtubule polymerization
C	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
C	0035330	biological_process	regulation of hippo signaling
C	0035331	biological_process	negative regulation of hippo signaling
C	0035556	biological_process	intracellular signal transduction
C	0040008	biological_process	regulation of growth
C	0043029	biological_process	T cell homeostasis
C	0045121	cellular_component	membrane raft
C	0045202	cellular_component	synapse
C	0045595	biological_process	regulation of cell differentiation
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0048156	molecular_function	tau protein binding
C	0050811	molecular_function	GABA receptor binding
C	0051321	biological_process	meiotic cell cycle
C	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0070062	cellular_component	extracellular exosome
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0090443	cellular_component	FAR/SIN/STRIPAK complex
C	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
C	0160232	cellular_component	INTAC complex
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
C	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
C	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
C	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
C	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000159	cellular_component	protein phosphatase type 2A complex
D	0000775	cellular_component	chromosome, centromeric region
D	0000785	cellular_component	chromatin
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0007059	biological_process	chromosome segregation
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016180	biological_process	snRNA processing
D	0016328	cellular_component	lateral plasma membrane
D	0019888	molecular_function	protein phosphatase regulator activity
D	0030425	cellular_component	dendrite
D	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
D	0035330	biological_process	regulation of hippo signaling
D	0035331	biological_process	negative regulation of hippo signaling
D	0035556	biological_process	intracellular signal transduction
D	0040008	biological_process	regulation of growth
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043029	biological_process	T cell homeostasis
D	0045202	cellular_component	synapse
D	0045595	biological_process	regulation of cell differentiation
D	0046982	molecular_function	protein heterodimerization activity
D	0051225	biological_process	spindle assembly
D	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
D	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0065003	biological_process	protein-containing complex assembly
D	0070062	cellular_component	extracellular exosome
D	0090443	cellular_component	FAR/SIN/STRIPAK complex
D	0098978	cellular_component	glutamatergic synapse
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	1990405	molecular_function	protein antigen binding
E	0000077	biological_process	DNA damage checkpoint signaling
E	0003674	molecular_function	molecular_function
E	0004864	molecular_function	protein phosphatase inhibitor activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0031929	biological_process	TOR signaling
E	0072542	molecular_function	protein phosphatase activator activity
F	0000159	cellular_component	protein phosphatase type 2A complex
F	0000278	biological_process	mitotic cell cycle
F	0000775	cellular_component	chromosome, centromeric region
F	0000785	cellular_component	chromatin
F	0000922	cellular_component	spindle pole
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0004722	molecular_function	protein serine/threonine phosphatase activity
F	0004725	molecular_function	protein tyrosine phosphatase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006470	biological_process	protein dephosphorylation
F	0010288	biological_process	response to lead ion
F	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
F	0015630	cellular_component	microtubule cytoskeleton
F	0016020	cellular_component	membrane
F	0016180	biological_process	snRNA processing
F	0016787	molecular_function	hydrolase activity
F	0031113	biological_process	regulation of microtubule polymerization
F	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
F	0035330	biological_process	regulation of hippo signaling
F	0035331	biological_process	negative regulation of hippo signaling
F	0035556	biological_process	intracellular signal transduction
F	0040008	biological_process	regulation of growth
F	0043029	biological_process	T cell homeostasis
F	0045121	cellular_component	membrane raft
F	0045202	cellular_component	synapse
F	0045595	biological_process	regulation of cell differentiation
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0048156	molecular_function	tau protein binding
F	0050811	molecular_function	GABA receptor binding
F	0051321	biological_process	meiotic cell cycle
F	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0070062	cellular_component	extracellular exosome
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0090443	cellular_component	FAR/SIN/STRIPAK complex
F	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
F	0160232	cellular_component	INTAC complex
F	0160240	biological_process	RNA polymerase II transcription initiation surveillance
F	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
F	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
F	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
F	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
F	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0000159	cellular_component	protein phosphatase type 2A complex
G	0000775	cellular_component	chromosome, centromeric region
G	0000785	cellular_component	chromatin
G	0004722	molecular_function	protein serine/threonine phosphatase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0007059	biological_process	chromosome segregation
G	0015630	cellular_component	microtubule cytoskeleton
G	0016020	cellular_component	membrane
G	0016180	biological_process	snRNA processing
G	0016328	cellular_component	lateral plasma membrane
G	0019888	molecular_function	protein phosphatase regulator activity
G	0030425	cellular_component	dendrite
G	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
G	0035330	biological_process	regulation of hippo signaling
G	0035331	biological_process	negative regulation of hippo signaling
G	0035556	biological_process	intracellular signal transduction
G	0040008	biological_process	regulation of growth
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0043029	biological_process	T cell homeostasis
G	0045202	cellular_component	synapse
G	0045595	biological_process	regulation of cell differentiation
G	0046982	molecular_function	protein heterodimerization activity
G	0051225	biological_process	spindle assembly
G	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
G	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
G	0065003	biological_process	protein-containing complex assembly
G	0070062	cellular_component	extracellular exosome
G	0090443	cellular_component	FAR/SIN/STRIPAK complex
G	0098978	cellular_component	glutamatergic synapse
G	0160232	cellular_component	INTAC complex
G	0160240	biological_process	RNA polymerase II transcription initiation surveillance
G	1990405	molecular_function	protein antigen binding
H	0000077	biological_process	DNA damage checkpoint signaling
H	0003674	molecular_function	molecular_function
H	0004864	molecular_function	protein phosphatase inhibitor activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0031929	biological_process	TOR signaling
H	0072542	molecular_function	protein phosphatase activator activity
I	0000159	cellular_component	protein phosphatase type 2A complex
I	0000278	biological_process	mitotic cell cycle
I	0000775	cellular_component	chromosome, centromeric region
I	0000785	cellular_component	chromatin
I	0000922	cellular_component	spindle pole
I	0004721	molecular_function	phosphoprotein phosphatase activity
I	0004722	molecular_function	protein serine/threonine phosphatase activity
I	0004725	molecular_function	protein tyrosine phosphatase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006470	biological_process	protein dephosphorylation
I	0010288	biological_process	response to lead ion
I	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0016180	biological_process	snRNA processing
I	0016787	molecular_function	hydrolase activity
I	0031113	biological_process	regulation of microtubule polymerization
I	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
I	0035330	biological_process	regulation of hippo signaling
I	0035331	biological_process	negative regulation of hippo signaling
I	0035556	biological_process	intracellular signal transduction
I	0040008	biological_process	regulation of growth
I	0043029	biological_process	T cell homeostasis
I	0045121	cellular_component	membrane raft
I	0045202	cellular_component	synapse
I	0045595	biological_process	regulation of cell differentiation
I	0046872	molecular_function	metal ion binding
I	0046982	molecular_function	protein heterodimerization activity
I	0048156	molecular_function	tau protein binding
I	0050811	molecular_function	GABA receptor binding
I	0051321	biological_process	meiotic cell cycle
I	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
I	0070062	cellular_component	extracellular exosome
I	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
I	0090443	cellular_component	FAR/SIN/STRIPAK complex
I	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
I	0160232	cellular_component	INTAC complex
I	0160240	biological_process	RNA polymerase II transcription initiation surveillance
I	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
I	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
I	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
I	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
I	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
I	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
J	0000159	cellular_component	protein phosphatase type 2A complex
J	0000775	cellular_component	chromosome, centromeric region
J	0000785	cellular_component	chromatin
J	0004722	molecular_function	protein serine/threonine phosphatase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0007059	biological_process	chromosome segregation
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0016180	biological_process	snRNA processing
J	0016328	cellular_component	lateral plasma membrane
J	0019888	molecular_function	protein phosphatase regulator activity
J	0030425	cellular_component	dendrite
J	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
J	0035330	biological_process	regulation of hippo signaling
J	0035331	biological_process	negative regulation of hippo signaling
J	0035556	biological_process	intracellular signal transduction
J	0040008	biological_process	regulation of growth
J	0043005	cellular_component	neuron projection
J	0043025	cellular_component	neuronal cell body
J	0043029	biological_process	T cell homeostasis
J	0045202	cellular_component	synapse
J	0045595	biological_process	regulation of cell differentiation
J	0046982	molecular_function	protein heterodimerization activity
J	0051225	biological_process	spindle assembly
J	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
J	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J	0065003	biological_process	protein-containing complex assembly
J	0070062	cellular_component	extracellular exosome
J	0090443	cellular_component	FAR/SIN/STRIPAK complex
J	0098978	cellular_component	glutamatergic synapse
J	0160232	cellular_component	INTAC complex
J	0160240	biological_process	RNA polymerase II transcription initiation surveillance
J	1990405	molecular_function	protein antigen binding
K	0000077	biological_process	DNA damage checkpoint signaling
K	0003674	molecular_function	molecular_function
K	0004864	molecular_function	protein phosphatase inhibitor activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0031929	biological_process	TOR signaling
K	0072542	molecular_function	protein phosphatase activator activity
L	0000159	cellular_component	protein phosphatase type 2A complex
L	0000278	biological_process	mitotic cell cycle
L	0000775	cellular_component	chromosome, centromeric region
L	0000785	cellular_component	chromatin
L	0000922	cellular_component	spindle pole
L	0004721	molecular_function	phosphoprotein phosphatase activity
L	0004722	molecular_function	protein serine/threonine phosphatase activity
L	0004725	molecular_function	protein tyrosine phosphatase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006470	biological_process	protein dephosphorylation
L	0010288	biological_process	response to lead ion
L	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
L	0015630	cellular_component	microtubule cytoskeleton
L	0016020	cellular_component	membrane
L	0016180	biological_process	snRNA processing
L	0016787	molecular_function	hydrolase activity
L	0031113	biological_process	regulation of microtubule polymerization
L	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
L	0035330	biological_process	regulation of hippo signaling
L	0035331	biological_process	negative regulation of hippo signaling
L	0035556	biological_process	intracellular signal transduction
L	0040008	biological_process	regulation of growth
L	0043029	biological_process	T cell homeostasis
L	0045121	cellular_component	membrane raft
L	0045202	cellular_component	synapse
L	0045595	biological_process	regulation of cell differentiation
L	0046872	molecular_function	metal ion binding
L	0046982	molecular_function	protein heterodimerization activity
L	0048156	molecular_function	tau protein binding
L	0050811	molecular_function	GABA receptor binding
L	0051321	biological_process	meiotic cell cycle
L	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
L	0070062	cellular_component	extracellular exosome
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090443	cellular_component	FAR/SIN/STRIPAK complex
L	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
L	0160232	cellular_component	INTAC complex
L	0160240	biological_process	RNA polymerase II transcription initiation surveillance
L	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
L	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
L	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
L	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
L	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
L	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MN F 501

Chain	Residue
F	HIS118
F	HIS241

---

site_id	AC2
Number of Residues	1
Details	binding site for residue MN I 501

Chain	Residue
I	HIS118

---

site_id	AC3
Number of Residues	1
Details	binding site for residue MN L 501

Chain	Residue
L	TYR265

---

site_id	AC4
Number of Residues	19
Details	binding site for Di-peptide ARG G 221 and ASP G 254

Chain	Residue
G	SER219
G	VAL220
G	LEU222
G	LEU223
G	ALA224
G	VAL225
G	GLN250
G	ALA251
G	ALA252
G	GLU253
G	LYS255
G	SER256
G	VAL259
G	ARG260
G	LEU212
G	ALA213
G	ASP215
G	GLN217
G	ASP218

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
C	LEU114-GLU119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	148
Details	Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	152
Details	Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	148
Details	Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	152
Details	Repeat: {"description":"HEAT 10","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P67774","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Leucine methyl ester","evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8206937","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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