5VZY

Crystal structure of crenezumab Fab in complex with Abeta

Replaces:  5KNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain	polymer	220	22997.6	1	UniProt (P0DOX5)	Homo sapiens	Immunoglobulin gamma-1 heavy chain NIE,Immunoglobulin gamma-1 heavy chain NIE
2	B (L)	Crenezumab Fab light chain,Immunoblobulin light chain	polymer	219	24064.8	1	UniProt (Q0KKI6)	Homo sapiens
3	C (A)	Amyloid beta A4 protein	polymer	15	1758.0	1	UniProt (P05067) Pfam (PF03494)	Homo sapiens (Human)	ABPP,APPI,APP,Alzheimer disease amyloid protein,Amyloid precursor protein,Beta-amyloid precursor protein,Cerebral vascular amyloid peptide,CVAP,PreA4,Protease nexin-II,PN-II
4	D, E, F (H, L, A)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

H: 1 - 108 (PDB: 5VZY)
H: 109 - 221 (UniProt: P0DOX5)
L: 1 - 104 (PDB: 5VZY)
L: 105 - 214 (UniProt: Q0KKI6)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	48820.3
All*	Total formula weight	48820.3

*Water molecules are not included.