5VZU
Crystal structure of the Skp1-FBXO31-cyclin D1 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | S-phase kinase-associated protein 1 | polymer | 149 | 16827.1 | 2 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB | Homo sapiens (Human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
2 | B, D | F-box only protein 31 | polymer | 488 | 55730.1 | 2 | UniProt (Q5XUX0) Pfam (PF12937) Pfam (PF12014) In PDB | Homo sapiens (Human) | |
3 | E, F | Cyclin D1 | polymer | 17 | 1971.0 | 2 | UniProt (Q9H014) UniProt (by SIFTS) (P24385) In PDB | Homo sapiens | |
4 | B, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | B, D | PHOSPHATE ION | non-polymer | 95.0 | 10 | Chemie (PO4) | |||
6 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, C: 1001 - 1163 (UniProt: P63208)
B, D: 66 - 539 (UniProt: Q5XUX0)
PDB | External Database | Details |
---|---|---|
Ala 1002 | Pro 2 | engineered mutation |
- | Asp 38 | deletion |
- | Glu 39 | deletion |
- | Gly 40 | deletion |
- | Asp 41 | deletion |
- | Asp 42 | deletion |
- | Asp 43 | deletion |
- | Pro 70 | deletion |
- | Pro 71 | deletion |
- | Pro 72 | deletion |
- | Glu 73 | deletion |
- | Asp 74 | deletion |
- | Asp 75 | deletion |
- | Glu 76 | deletion |
- | Asn 77 | deletion |
Gly 1078 | Lys 78 | see remark 999 |
Gly 1079 | Glu 79 | see remark 999 |
Ser 1080 | Lys 80 | see remark 999 |
Gly 1081 | Arg 81 | see remark 999 |
PDB | External Database | Details |
---|---|---|
Met 52 | - | expression tag |
Ala 53 | - | expression tag |
Ser 54 | - | expression tag |
Trp 55 | - | expression tag |
Ser 56 | - | expression tag |
His 57 | - | expression tag |
Pro 58 | - | expression tag |
Gln 59 | - | expression tag |
Phe 60 | - | expression tag |
Glu 61 | - | expression tag |
Lys 62 | - | expression tag |
Ser 63 | - | expression tag |
Gly 64 | - | expression tag |
Arg 65 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 149056.5 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1080.5 | |
All* | Total formula weight | 150137.0 |