5VYC
Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, BD, JA, KE, SB... (T1, T2, T3, T4, T5...) | 40S ribosomal protein S19 | polymer | 145 | 16091.6 | 6 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (Human) | Small ribosomal subunit protein eS19 |
| 2 | B, CD, KA, LE, TB... (U1, U2, U3, U4, U5...) | 40S ribosomal protein S20 | polymer | 119 | 13398.8 | 6 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (Human) | Small ribosomal subunit protein uS10 |
| 3 | C, DD, LA, ME, UB... (V1, V2, V3, V4, V5...) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 6 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (Human) | Small ribosomal subunit protein eS21 |
| 4 | D, ED, MA, NE, VB... (X1, X2, X3, X4, X5...) | 40S ribosomal protein S23 | polymer | 143 | 15844.7 | 6 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (Human) | Small ribosomal subunit protein uS12 |
| 5 | E, FD, NA, OE, WB... (a1, a2, a3, a4, a5...) | 40S ribosomal protein S26 | polymer | 115 | 13047.5 | 6 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (Human) | Small ribosomal subunit protein eS26 |
| 6 | F, GD, OA, PE, XB... (c1, c2, c3, c4, c5...) | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 6 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (Human) | Small ribosomal subunit protein eS28 |
| 7 | G, HD, PA, QE, YB... (d1, d2, d3, d4, d5...) | 40S ribosomal protein S29 | polymer | 56 | 6690.8 | 6 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (Human) | Small ribosomal subunit protein uS14 |
| 8 | AG, H, ID, QA, RE... (f1, f2, f3, f4, f5...) | Ribosomal protein S27a | polymer | 156 | 17944.0 | 6 | UniProt (Q5RKT7) Pfam (PF00240) Pfam (PF01599) | Homo sapiens (Human) | |
| 9 | AC, BG, I, JD, RA... (g1, g2, g3, g4, g5...) | Receptor of activated protein C kinase 1 | polymer | 317 | 35115.7 | 6 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (Human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 10 | BC, CG, J, KD, SA... (C1, C2, C3, C4, C5...) | 40S ribosomal protein S2 | polymer | 293 | 31376.5 | 6 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (Human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 11 | CC, DG, K, LD, TA... (G1, G2, G3, G4, G5...) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 6 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (Human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 12 | DC, EG, L, MD, UA... (J1, J2, J3, J4, J5...) | 40S ribosomal protein S9 | polymer | 194 | 22641.6 | 6 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (Human) | Small ribosomal subunit protein uS4 |
| 13 | EC, FG, M, ND, VA... (M1, M2, M3, M4, M5...) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 6 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (Human) | Small ribosomal subunit protein eS12 |
| 14 | FC, GG, N, OD, WA... (N1, N2, N3, N4, N5...) | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 6 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (Human) | Small ribosomal subunit protein uS15 |
| 15 | GC, HG, O, PD, XA... (O1, O2, O3, O4, O5...) | 40S ribosomal protein S14 | polymer | 151 | 16302.8 | 6 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (Human) | Small ribosomal subunit protein uS11 |
| 16 | HC, IG, P, QD, YA... (W1, W2, W3, W4, W5...) | 40S ribosomal protein S15a | polymer | 130 | 14865.6 | 6 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (Human) | Small ribosomal subunit protein uS8 |
| 17 | AF, IC, JG, Q, RD... (Y1, Y2, Y3, Y4, Y5...) | 40S ribosomal protein S24 | polymer | 133 | 15463.3 | 6 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (Human) | Small ribosomal subunit protein eS24 |
| 18 | AB, BF, JC, KG, R... (Z1, Z2, Z3, Z4, Z5...) | 40S ribosomal protein S25 | polymer | 125 | 13776.2 | 6 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (Human) | Small ribosomal subunit protein eS25 |
| 19 | BB, CF, KC, LG, S... (b1, b2, b3, b4, b5...) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 6 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (Human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 20 | CB, DF, LC, MG, T... (e1, e2, e3, e4, e5...) | 40S ribosomal protein S30 | polymer | 133 | 14415.7 | 6 | UniProt (E9PR30) Pfam (PF04758) | Homo sapiens (Human) | |
| 21 | DB, EF, MC, NG, U... (i1, i2, i3, i4, i5...) | Human 18S ribosomal RNA | polymer | 1869 | 602752.9 | 6 | GenBank (36162) | Homo sapiens | |
| 22 | EB, FF, NC, OG, V... (A1, A2, A3, A4, A5...) | 40S ribosomal protein SA | polymer | 295 | 32883.9 | 6 | UniProt (P08865) Pfam (PF00318) Pfam (PF16122) | Homo sapiens (Human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 23 | FB, GF, OC, PG, W... (B1, B2, B3, B4, B5...) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 6 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (Human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 24 | GB, HF, PC, QG, X... (D1, D2, D3, D4, D5...) | 40S ribosomal protein S3 | polymer | 243 | 26729.4 | 6 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (Human) | Small ribosomal subunit protein uS3 |
| 25 | HB, IF, QC, RG, Y... (E1, E2, E3, E4, E5...) | 40S ribosomal protein S4, X isoform | polymer | 263 | 29654.9 | 6 | UniProt (P62701) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) Pfam (PF08071) | Homo sapiens (Human) | SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4 |
| 26 | AE, IB, JF, RC, SG... (F1, F2, F3, F4, F5...) | 40S ribosomal protein S5 | polymer | 204 | 22913.5 | 6 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (Human) | Small ribosomal subunit protein uS7 |
| 27 | AA, BE, JB, KF, SC... (H1, H2, H3, H4, H5...) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 6 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (Human) | Small ribosomal subunit protein eS7 |
| 28 | BA, CE, KB, LF, TC... (I1, I2, I3, I4, I5...) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 6 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (Human) | Small ribosomal subunit protein eS8 |
| 29 | CA, DE, LB, MF, UC... (K1, K2, K3, K4, K5...) | 40S ribosomal protein S10 | polymer | 165 | 18933.8 | 6 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (Human) | Small ribosomal subunit protein eS10 |
| 30 | DA, EE, MB, NF, VC... (L1, L2, L3, L4, L5...) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 6 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (Human) | Small ribosomal subunit protein uS17 |
| 31 | EA, FE, NB, OF, WC... (P1, P2, P3, P4, P5...) | 40S ribosomal protein S15 | polymer | 145 | 17076.2 | 6 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (Human) | RIG protein,Small ribosomal subunit protein uS19 |
| 32 | FA, GE, OB, PF, XC... (Q1, Q2, Q3, Q4, Q5...) | 40S ribosomal protein S16 | polymer | 146 | 16477.4 | 6 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (Human) | Small ribosomal subunit protein uS9 |
| 33 | GA, HE, PB, QF, YC... (R1, R2, R3, R4, R5...) | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 6 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (Human) | Small ribosomal subunit protein eS17 |
| 34 | AH, HA, IE, QB, RF... (S1, S2, S3, S4, S5...) | 40S ribosomal protein S18 | polymer | 152 | 17759.8 | 6 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (Human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 35 | AD, BH, IA, JE, RB... (j1, j2, j3, j4, j5...) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 6 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (Human) | HG12,Large ribosomal subunit protein eL41 |
| 36 | CH, DH, EH, FH, GH... (k1, k2, k3, k4, k5...) | Malignant T-cell-amplified sequence 1 | polymer | 181 | 20585.3 | 6 | UniProt (Q9ULC4) Pfam (PF17832) Pfam (PF01472) | Homo sapiens (Human) | MCT-1,Multiple copies T-cell malignancies |
| 37 | IH, JH, KH, LH, MH... (l1, l2, l3, l4, l5...) | Density-regulated protein | polymer | 198 | 22124.0 | 6 | UniProt (O43583) Pfam (PF21023) Pfam (PF01253) | Homo sapiens (Human) | DRP,Protein DRP1,Smooth muscle cell-associated protein 3,SMAP-3 |
| 38 | OH, PH, QH, RH, SH... (f1, f2, f3, f4, f5...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
e1, e2, e3, e4, e5, e6: -73 - 59 (UniProt: E9PR30)
i1, i2, i3, i4, i5, i6: 1 - 1869 (GenBank: 36162)
| PDB | External Database | Details |
|---|---|---|
| Ala -48 | - | insertion |
| His -47 | - | insertion |
| Val -46 | - | insertion |
| Ala -45 | - | insertion |
| Ser -44 | - | insertion |
| Leu -43 | - | insertion |
| Glu -42 | - | insertion |
| Gly -41 | - | insertion |
| Ile -40 | - | insertion |
| Ala -39 | - | insertion |
| Pro -38 | - | insertion |
| Glu -37 | - | insertion |
| Asp -36 | - | insertion |
| Gln -35 | - | insertion |
| Val -34 | - | insertion |
| Val -33 | - | insertion |
| Leu -32 | - | insertion |
| Leu -31 | - | insertion |
| Ala -30 | - | insertion |
| Gly -29 | - | insertion |
| Ala -28 | - | insertion |
| Pro -27 | - | insertion |
| Leu -26 | - | insertion |
| Glu -25 | - | insertion |
| Asp -24 | - | insertion |
| Glu -23 | - | insertion |
| Ala -22 | - | insertion |
| Thr -21 | - | insertion |
| Leu -20 | - | insertion |
| Gly -19 | - | insertion |
| Gln -18 | - | insertion |
| Cys -17 | - | insertion |
| Gly -16 | - | insertion |
| Val -15 | - | insertion |
| Glu -14 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| C 582 | U 582 | conflict |
| C 583 | A 583 | conflict |
| G 584 | A 584 | conflict |
| A 798 | G 798 | conflict |
| U 1095 | C 1095 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 222 |
| Total formula weight | 7654982.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 7655375.2 |
