5VXA
Structure of the human Mesh1-NADPH complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 | polymer | 180 | 20514.3 | 2 | UniProt (Q8N4P3) Pfam (PF13328) | Homo sapiens (Human) | HD domain-containing protein 3,Metazoan SpoT homolog 1,MESH1,Penta-phosphate guanosine-3'-pyrophosphohydrolase,(ppGpp)ase |
| 2 | C, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, J (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | E, F, K (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | G, L (A, B) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 6 | H (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | M (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 8 | N, O (A, B) | water | water | 18.0 | 256 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 179 (UniProt: Q8N4P3)
| PDB | External Database | Details |
|---|---|---|
| His 0 | - | expression tag |
| Lys 66 | Asp 66 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41028.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2109.3 | |
| All* | Total formula weight | 43137.8 |
