5VWV

Bak core latch dimer in complex with Bim-BH3 - Cubic

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Bcl-2 homologous antagonist/killer	polymer	170	19037.3	1	UniProt (Q16611) Pfam (PF00452) In PDB	Homo sapiens (Human)	Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7
2	B	Bcl-2-like protein 11	polymer	25	3026.4	1	UniProt (O43521) Pfam (PF08945) In PDB	Homo sapiens	Bcl2-L-11,Bcl2-interacting mediator of cell death
3	A	trifluoroacetic acid	non-polymer		114.0	1	Chemie (TFA)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
5	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7		water	water		18.0	186	Chemie (HOH)

Sequence modifications

A: 23 - 186 (UniProt: Q16611)

PDB	External Database	Details
Gly 17	-	expression tag
Pro 18	-	expression tag
Leu 19	-	expression tag
Gly 20	-	expression tag
Ser 21	-	expression tag
Met 22	-	expression tag
Ser 166	Cys 166	engineered mutation

B: 141 - 165 (UniProt: O43521)

PDB	External Database	Details
Arg 147	Trp 147	engineered mutation
Thr 162	Tyr 162	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	22063.7
Non-Polymers*	Number of molecules	9
	Total formula weight	614.0
All*	Total formula weight	22677.7

*Water molecules are not included.