5VQ1

Crystal structure of human KRAS Q61A mutant in complex with GDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	GTPase KRas	polymer	170	19336.8	2	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A, B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	B	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
5		water	water		18.0	146	Chemie (HOH)

Sequence modifications

A, B: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
His 0	-	expression tag
Ala 61	Gln 61	engineered mutation
Ser 118	Cys 118	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38673.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1129.2
All*	Total formula weight	39802.8

*Water molecules are not included.