5VP7
Crystal structure of human KRAS G12A mutant in complex with GDP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, F) | GTPase KRas | polymer | 170 | 19407.9 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, G (A, F) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 3 | D, H (A, F) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 5 | F, I (A, F) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | J, K (A, F) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, F: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| His 0 | - | expression tag |
| Ala 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38815.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1131.2 | |
| All* | Total formula weight | 39946.9 |
