5VP7

Crystal structure of human KRAS G12A mutant in complex with GDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	GTPase KRas	polymer	170	19407.9	2	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A, F	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
3	A, F	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
5	A, F	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6		water	water		18.0	201	Chemie (HOH)

Sequence modifications

A, F: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
His 0	-	expression tag
Ala 12	Gly 12	engineered mutation
Ser 118	Cys 118	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38815.7
Non-Polymers*	Number of molecules	7
	Total formula weight	1131.2
All*	Total formula weight	39946.9

*Water molecules are not included.