5VP7
Crystal structure of human KRAS G12A mutant in complex with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| F | 0003924 | molecular_function | GTPase activity |
| F | 0005525 | molecular_function | GTP binding |
| F | 0007165 | biological_process | signal transduction |
| F | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue GDP A 201 |
| Chain | Residue |
| A | GLY13 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH311 |
| A | HOH318 |
| A | VAL14 |
| A | HOH339 |
| A | HOH341 |
| A | HOH372 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| A | ASP30 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | GDP201 |
| A | HOH305 |
| A | HOH311 |
| A | HOH341 |
| A | HOH360 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PGE A 203 |
| Chain | Residue |
| A | ASP154 |
| F | ASP153 |
| F | ASP154 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 204 |
| Chain | Residue |
| A | ALA18 |
| A | ILE21 |
| A | GLN22 |
| A | HIS27 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue GDP F 201 |
| Chain | Residue |
| F | GLY13 |
| F | VAL14 |
| F | GLY15 |
| F | LYS16 |
| F | SER17 |
| F | ALA18 |
| F | PHE28 |
| F | VAL29 |
| F | ASP30 |
| F | ASN116 |
| F | LYS117 |
| F | ASP119 |
| F | LEU120 |
| F | SER145 |
| F | ALA146 |
| F | LYS147 |
| F | MG202 |
| F | HOH316 |
| F | HOH324 |
| F | HOH346 |
| F | HOH375 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG F 202 |
| Chain | Residue |
| F | SER17 |
| F | GDP201 |
| F | HOH304 |
| F | HOH316 |
| F | HOH346 |
| F | HOH352 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA F 203 |
| Chain | Residue |
| F | ALA18 |
| F | ILE21 |
| F | GLN22 |
| F | HIS27 |
| F | PHE28 |
| F | VAL29 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
