5VOD
Crystal structure of HCMV Pentamer in complex with neutralizing antibody 9I6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Envelope glycoprotein H | polymer | 725 | 82415.9 | 1 | UniProt (Q6SW67) Pfam (PF02489) Pfam (PF17488) | Human cytomegalovirus (HHV-5) | gH |
| 2 | B (B) | Envelope glycoprotein L | polymer | 278 | 30846.5 | 1 | UniProt (Q68674) | Human cytomegalovirus (strain 5508) (HHV-5) | gL |
| 3 | C (C) | Envelope glycoprotein UL128 | polymer | 171 | 19777.0 | 1 | UniProt (P16837) Pfam (PF25700) | Human cytomegalovirus (strain AD169) (HHV-5) | |
| 4 | D (D) | Envelope glycoprotein UL130 | polymer | 252 | 28664.6 | 1 | UniProt (F5HCP3) Pfam (PF11668) | Human cytomegalovirus (strain Merlin) (HHV-5) | |
| 5 | E (E) | Envelope glycoprotein UL131A | polymer | 129 | 15011.0 | 1 | UniProt (F5HET4) | Human cytomegalovirus (strain Merlin) (HHV-5) | |
| 6 | F (H) | Fab 9I6 heavy chain | polymer | 288 | 30610.3 | 1 | UniProt (S6B291) | Homo sapiens (Human) | |
| 7 | G (L) | Fab 9I6 light chain | polymer | 241 | 26621.7 | 1 | UniProt (Q8TCD0) | Homo sapiens (Human) | |
| 8 | H, I, L (F, G, K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 9 | J, M (I, M) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 10 | K (J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
A: 1 - 715 (UniProt: Q6SW67)
D: 1 - 214 (UniProt: F5HCP3)
H: 1 - 135 (PDB: 5VOD)
H: 136 - 245 (UniProt: S6B291)
L: -19 - 104 (PDB: 5VOD)
L: 105 - 221 (UniProt: Q8TCD0)
| PDB | External Database | Details |
|---|---|---|
| Gly 716 | - | expression tag |
| Ser 717 | - | expression tag |
| Gly 718 | - | expression tag |
| Ser 719 | - | expression tag |
| His 720 | - | expression tag |
| His 721 | - | expression tag |
| His 722 | - | expression tag |
| His 723 | - | expression tag |
| His 724 | - | expression tag |
| His 725 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Ser 216 | - | expression tag |
| Glu 217 | - | expression tag |
| Asn 218 | - | expression tag |
| Leu 219 | - | expression tag |
| Tyr 220 | - | expression tag |
| Phe 221 | - | expression tag |
| Gln 222 | - | expression tag |
| Ala 223 | - | expression tag |
| Gly 224 | - | expression tag |
| Trp 225 | - | expression tag |
| Ser 226 | - | expression tag |
| His 227 | - | expression tag |
| Pro 228 | - | expression tag |
| Gln 229 | - | expression tag |
| Phe 230 | - | expression tag |
| Glu 231 | - | expression tag |
| Lys 232 | - | expression tag |
| Gly 233 | - | expression tag |
| Gly 234 | - | expression tag |
| Gly 235 | - | expression tag |
| Ser 236 | - | expression tag |
| Gly 237 | - | expression tag |
| Gly 238 | - | expression tag |
| Gly 239 | - | expression tag |
| Ser 240 | - | expression tag |
| Gly 241 | - | expression tag |
| Gly 242 | - | expression tag |
| Gly 243 | - | expression tag |
| Ser 244 | - | expression tag |
| Trp 245 | - | expression tag |
| Ser 246 | - | expression tag |
| His 247 | - | expression tag |
| Pro 248 | - | expression tag |
| Gln 249 | - | expression tag |
| Phe 250 | - | expression tag |
| Glu 251 | - | expression tag |
| Lys 252 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ser 246 | - | expression tag |
| Ser 247 | - | expression tag |
| Gly 248 | - | expression tag |
| Leu 249 | - | expression tag |
| Glu 250 | - | expression tag |
| Val 251 | - | expression tag |
| Leu 252 | - | expression tag |
| Phe 253 | - | expression tag |
| Gln 254 | - | expression tag |
| Gly 255 | - | expression tag |
| Pro 256 | - | expression tag |
| Leu 257 | - | expression tag |
| Gly 258 | - | expression tag |
| Ser 259 | - | expression tag |
| Ala 260 | - | expression tag |
| Trp 261 | - | expression tag |
| Ser 262 | - | expression tag |
| His 263 | - | expression tag |
| Pro 264 | - | expression tag |
| Gln 265 | - | expression tag |
| Phe 266 | - | expression tag |
| Glu 267 | - | expression tag |
| Lys 268 | - | expression tag |
| Gly 269 | - | expression tag |
| Gly 270 | - | expression tag |
| Gly 271 | - | expression tag |
| Ser 272 | - | expression tag |
| Gly 273 | - | expression tag |
| Gly 274 | - | expression tag |
| Gly 275 | - | expression tag |
| Ser 276 | - | expression tag |
| Gly 277 | - | expression tag |
| Gly 278 | - | expression tag |
| Gly 279 | - | expression tag |
| Ser 280 | - | expression tag |
| Trp 281 | - | expression tag |
| Ser 282 | - | expression tag |
| His 283 | - | expression tag |
| Pro 284 | - | expression tag |
| Gln 285 | - | expression tag |
| Phe 286 | - | expression tag |
| Glu 287 | - | expression tag |
| Lys 288 | - | expression tag |
L: 105 - 221 (UniProt: Q8TCD0)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 233947.1 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4005.7 | |
| All* | Total formula weight | 237952.8 |
