5VLA

Short PCSK9 delta-P' complex with Fusion2 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proprotein convertase subtilisin/kexin type 9	polymer	460	49784.1	1	UniProt (Q8NBP7) Pfam (PF05922) Pfam (PF00082) In PDB	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
2	Z	THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-MET-PRO-TRP-ASN-LEU-VAL-ARG-ILE-GLY-LEU-LEU	polymer	30	3556.1	1		synthetic construct
3	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4		water	water		18.0	127	Chemie (HOH)

Sequence modifications

A: 1 - 452 (UniProt: Q8NBP7)

PDB	External Database	Details
Ser 167	Arg 167	engineered mutation
Asn 453	-	expression tag
Ser 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53340.2
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	53420.3

*Water molecules are not included.