5VLA

Short PCSK9 delta-P' complex with Fusion2 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CA A 501

Chain	Residue
A	PRO331
A	VAL333
A	ASP360
A	HOH623
A	HOH650
A	HOH688
A	HOH690

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site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 502

Chain	Residue
A	HOH708
A	HOH631
A	HOH635

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240

Chain	Residue	Details
A	ASP186
A	HIS226
A	SER386

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:14622975

Chain	Residue	Details
A	GLN152

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035

Chain	Residue	Details
A	ARG218

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035

Chain	Residue	Details
A	TYR38

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER47

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