5VKC
Crystal structure of MCL-1 in complex with a BIM competitive inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 157 | 17882.4 | 2 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | C, K (A, B) | 7-(3-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-1,5-dimethyl-1H-pyrazol-4-yl)-3-{3-[(naphthalen-1-yl)oxy]propyl}-1-[(pyridin-3-yl)methyl]-1H-indole-2-carboxylic acid | non-polymer | 762.9 | 2 | Chemie (9EA) | |||
| 3 | D, E, F, G, H... (A, B) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 4 | O, P (A, B) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A, B: 174 - 326 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| Met 172 | - | expression tag |
| Asp 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35764.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2179.9 | |
| All* | Total formula weight | 37944.7 |
