5VFO
Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (G, g) | Proteasome subunit alpha type-6 | polymer | 240 | 26727.7 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | 27 kDa prosomal protein, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain, alpha1 |
| 2 | B, P (H, h) | Proteasome subunit alpha type-2 | polymer | 232 | 25725.3 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3, alpha2 |
| 3 | C, Q (I, i) | Proteasome subunit alpha type-4 | polymer | 250 | 28118.2 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L, alpha3 |
| 4 | D, R (J, j) | Proteasome subunit alpha type-7 | polymer | 243 | 27382.2 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Proteasome subunit RC6-1, Proteasome subunit XAPC7, alpha4 |
| 5 | E, S (K, k) | Proteasome subunit alpha type-5 | polymer | 234 | 25570.0 | 2 | UniProt (P28066) Pfam (PF00227) Pfam (PF10584) | Homo sapiens (Human) | Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, alpha5 |
| 6 | F, T (L, l) | Proteasome subunit alpha type-1 | polymer | 238 | 26728.4 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | 30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, alpha6 |
| 7 | G, U (M, m) | Proteasome subunit alpha type-3 | polymer | 245 | 27287.1 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, alpha7 |
| 8 | H, V (N, n) | Proteasome subunit beta type-6 | polymer | 191 | 20471.1 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (Human) | Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y, beta1 |
| 9 | I, W (O, o) | Proteasome subunit beta type-7 | polymer | 220 | 23745.3 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (Human) | Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z, beta2 |
| 10 | J, X (P, p) | Proteasome subunit beta type-3 | polymer | 204 | 22841.7 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (Human) | Proteasome chain 13, Proteasome component C10-II, Proteasome theta chain, beta3 |
| 11 | K, Y (Q, q) | Proteasome subunit beta type-2 | polymer | 199 | 22720.1 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I, beta4 |
| 12 | L, Z (R, r) | Proteasome subunit beta type-5 | polymer | 201 | 22199.1 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (Human) | Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, beta5 |
| 13 | AA, M (S, s) | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain, beta6 |
| 14 | BA, N (T, t) | Proteasome subunit beta type-4 | polymer | 215 | 23994.3 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (Human) | 26 kDa prosomal protein, PROS-26, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3, HsN3, beta7 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 694178.8 | |
| All* | Total formula weight | 694178.8 |
