5VFO

Nucleotide-driven Triple-state Remodeling of the AAA-ATPase Channel in the Activated Human 26S Proteasome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G, g	Proteasome subunit alpha type-6	polymer	240	26727.7	2	UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	27 kDa prosomal protein, p27K, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, Proteasome iota chain, alpha1
2	H, h	Proteasome subunit alpha type-2	polymer	232	25725.3	2	UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3, alpha2
3	I, i	Proteasome subunit alpha type-4	polymer	250	28118.2	2	UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome component C9, Proteasome subunit L, alpha3
4	J, j	Proteasome subunit alpha type-7	polymer	243	27382.2	2	UniProt (O14818) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Proteasome subunit RC6-1, Proteasome subunit XAPC7, alpha4
5	K, k	Proteasome subunit alpha type-5	polymer	234	25570.0	2	UniProt (P28066) Pfam (PF00227) Pfam (PF10584) In PDB	Homo sapiens (Human)	Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, alpha5
6	L, l	Proteasome subunit alpha type-1	polymer	238	26728.4	2	UniProt (P25786) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	30 kDa prosomal protein, PROS-30, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome component C2, Proteasome nu chain, alpha6
7	M, m	Proteasome subunit alpha type-3	polymer	245	27287.1	2	UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, alpha7
8	N, n	Proteasome subunit beta type-6	polymer	191	20471.1	2	UniProt (P28072) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome delta chain, Proteasome subunit Y, beta1
9	O, o	Proteasome subunit beta type-7	polymer	220	23745.3	2	UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) In PDB	Homo sapiens (Human)	Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome subunit Z, beta2
10	P, p	Proteasome subunit beta type-3	polymer	204	22841.7	2	UniProt (P49720) Pfam (PF00227) In PDB	Homo sapiens (Human)	Proteasome chain 13, Proteasome component C10-II, Proteasome theta chain, beta3
11	Q, q	Proteasome subunit beta type-2	polymer	199	22720.1	2	UniProt (P49721) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I, beta4
12	R, r	Proteasome subunit beta type-5	polymer	201	22199.1	2	UniProt (P28074) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X, beta5
13	S, s	Proteasome subunit beta type-1	polymer	213	23579.0	2	UniProt (P20618) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome component C5, Proteasome gamma chain, beta6
14	T, t	Proteasome subunit beta type-4	polymer	215	23994.3	2	UniProt (P28070) Pfam (PF00227) In PDB	Homo sapiens (Human)	26 kDa prosomal protein, PROS-26, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3, HsN3, beta7

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	694178.8
All*	Total formula weight	694178.8

*Water molecules are not included.