5VCV
CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Dasatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | polymer | 311 | 34578.1 | 1 | UniProt (Q99640) Pfam (PF00069) | Homo sapiens (Human) | Myt1 kinase |
| 2 | B, C (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | E (A) | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 1 | Chemie (1N1) | |||
| 5 | F (A) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A: 75 - 362 (UniProt: Q99640)
| PDB | External Database | Details |
|---|---|---|
| Met 52 | - | initiating methionine |
| His 53 | - | expression tag |
| His 54 | - | expression tag |
| His 55 | - | expression tag |
| His 56 | - | expression tag |
| His 57 | - | expression tag |
| His 58 | - | expression tag |
| Ser 59 | - | expression tag |
| Ser 60 | - | expression tag |
| Gly 61 | - | expression tag |
| Val 62 | - | expression tag |
| Asp 63 | - | expression tag |
| Leu 64 | - | expression tag |
| Gly 65 | - | expression tag |
| Thr 66 | - | expression tag |
| Glu 67 | - | expression tag |
| Asn 68 | - | expression tag |
| Leu 69 | - | expression tag |
| Tyr 70 | - | expression tag |
| Phe 71 | - | expression tag |
| Gln 72 | - | expression tag |
| Ser 73 | - | expression tag |
| Met 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34578.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 621.0 | |
| All* | Total formula weight | 35199.1 |
