5VB2
Crystal structure of the NavAb voltage-gated sodium channel in a closed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Ion transport protein | polymer | 285 | 33225.2 | 4 | UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016) | Arcobacter butzleri | |
| 2 | E, F, K, L, R... (A, B, C, D) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 8 | Chemie (CPS) | |||
| 3 | AA, BA, CA, G, H... (D, A, B, C) | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 678.9 | 13 | Chemie (PX4) | |||
| 4 | DA, J, Q, W (D, A, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | X (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | EA, FA, GA, HA (A, B, C, D) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1001 - 1267 (UniProt: A8EVM5)
| PDB | External Database | Details |
|---|---|---|
| Met 983 | - | initiating methionine |
| Asp 984 | - | expression tag |
| Tyr 985 | - | expression tag |
| Lys 986 | - | expression tag |
| Asp 987 | - | expression tag |
| Asp 988 | - | expression tag |
| Asp 989 | - | expression tag |
| Asp 990 | - | expression tag |
| Lys 991 | - | expression tag |
| Gly 992 | - | expression tag |
| Ser 993 | - | expression tag |
| Leu 994 | - | expression tag |
| Val 995 | - | expression tag |
| Pro 996 | - | expression tag |
| Arg 997 | - | expression tag |
| Gly 998 | - | expression tag |
| Ser 999 | - | expression tag |
| His 1000 | - | expression tag |
| Phe 1206 | Thr 206 | engineered mutation |
| Tyr 1213 | Val 213 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 132900.9 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 14160.6 | |
| All* | Total formula weight | 147061.4 |
