5VB2
Crystal structure of the NavAb voltage-gated sodium channel in a closed conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0086010 | biological_process | membrane depolarization during action potential |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0086010 | biological_process | membrane depolarization during action potential |
| C | 0001518 | cellular_component | voltage-gated sodium channel complex |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005248 | molecular_function | voltage-gated sodium channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0086010 | biological_process | membrane depolarization during action potential |
| D | 0001518 | cellular_component | voltage-gated sodium channel complex |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005248 | molecular_function | voltage-gated sodium channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0086010 | biological_process | membrane depolarization during action potential |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CPS A 1301 |
| Chain | Residue |
| A | GLY1129 |
| A | ILE1216 |
| A | ASP1219 |
| A | ILE1223 |
| A | HOH1405 |
| D | ILE2119 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CPS A 1302 |
| Chain | Residue |
| B | VAL2218 |
| B | ASP2219 |
| A | SER1125 |
| A | VAL1126 |
| A | ALA1220 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue PX4 A 1303 |
| Chain | Residue |
| A | MET1188 |
| A | PRO1192 |
| A | TRP1195 |
| A | HOH1401 |
| D | MET2137 |
| D | THR2162 |
| D | GLY2164 |
| D | GLU2165 |
| D | PHE2167 |
| D | TYR2168 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 A 1304 |
| Chain | Residue |
| A | GLY1030 |
| A | SER1034 |
| B | THR2162 |
| B | GLY2164 |
| B | PX42306 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 A 1305 |
| Chain | Residue |
| A | PHE1144 |
| A | ARG1155 |
| A | TYR1191 |
| A | TYR1193 |
| A | HOH1402 |
| D | ILE2097 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 1306 |
| Chain | Residue |
| A | TRP1076 |
| A | SER1121 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue CPS B 2301 |
| Chain | Residue |
| A | ILE1119 |
| B | GLY2129 |
| B | ILE2216 |
| B | ASP2219 |
| B | ALA2220 |
| B | ILE2223 |
| B | HOH2404 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CPS B 2302 |
| Chain | Residue |
| B | ALA2122 |
| B | SER2125 |
| B | VAL2126 |
| B | ILE2223 |
| B | LEU2224 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue PX4 B 2303 |
| Chain | Residue |
| A | ILE1097 |
| B | LEU2151 |
| B | PHE2152 |
| B | ARG2155 |
| B | TYR2191 |
| B | VAL2196 |
| B | HOH2405 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue PX4 B 2304 |
| Chain | Residue |
| A | MET1137 |
| A | PHE1141 |
| A | GLY1164 |
| A | PHE1167 |
| A | TYR1168 |
| B | MET2188 |
| B | PRO2192 |
| B | TRP2195 |
| D | PX42303 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue PX4 B 2305 |
| Chain | Residue |
| B | GLY2030 |
| B | LEU2031 |
| B | SER2034 |
| B | THR2036 |
| C | TYR1142 |
| C | THR1162 |
| C | GLY1164 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue PX4 B 2306 |
| Chain | Residue |
| A | PX41304 |
| B | MET2137 |
| B | PHE2141 |
| B | GLY2164 |
| B | GLU2165 |
| B | HOH2403 |
| C | MET1188 |
| C | PRO1192 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CPS C 1301 |
| Chain | Residue |
| C | SER1125 |
| C | VAL1126 |
| C | ALA1220 |
| D | VAL2218 |
| D | ASP2219 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CPS C 1302 |
| Chain | Residue |
| B | ILE2119 |
| C | GLY1129 |
| C | ILE1216 |
| C | ASP1219 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 C 1303 |
| Chain | Residue |
| C | GLY1030 |
| C | LEU1031 |
| C | SER1034 |
| D | THR2162 |
| D | LEU2163 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 C 1304 |
| Chain | Residue |
| C | GLY1164 |
| C | GLU1165 |
| C | PHE1167 |
| C | TYR1168 |
| D | MET2188 |
| D | TRP2195 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue PX4 C 1305 |
| Chain | Residue |
| C | LEU1151 |
| C | PHE1152 |
| C | VAL1190 |
| C | TYR1191 |
| C | TYR1193 |
| C | HOH1404 |
| B | ILE2097 |
| C | PHE1144 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 C 1306 |
| Chain | Residue |
| C | SER1121 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 1307 |
| Chain | Residue |
| A | HIS1239 |
| B | HIS2239 |
| C | HIS1239 |
| D | HIS2239 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue CPS D 2301 |
| Chain | Residue |
| C | ILE1119 |
| D | GLY2129 |
| D | ASP2219 |
| D | ALA2220 |
| D | ILE2223 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue CPS D 2302 |
| Chain | Residue |
| A | ASP1219 |
| D | ALA2122 |
| D | SER2125 |
| D | VAL2126 |
| D | ILE2223 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 D 2303 |
| Chain | Residue |
| A | THR1162 |
| A | GLY1164 |
| B | PX42304 |
| D | GLY2030 |
| D | LEU2031 |
| D | SER2034 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 D 2304 |
| Chain | Residue |
| C | ILE1097 |
| D | LEU2151 |
| D | TYR2191 |
| D | TYR2193 |
| D | VAL2196 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue PX4 D 2305 |
| Chain | Residue |
| D | PRO2075 |
| D | TRP2076 |
| D | PHE2079 |
| D | SER2121 |
| D | ILE2124 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 D 2306 |
| Chain | Residue |
| C | GLN1115 |
| D | SER2132 |
