5VAY

Bcl-2 complex with Beclin 1 T108D BH3 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera	polymer	168	19501.7	4	UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X
2	E, F, G, H (E, G, F, H)	Beclin-1	polymer	26	2859.2	4	UniProt (Q14457) Pfam (PF15285)	Homo sapiens	Coiled-coil myosin-like BCL2-interacting protein,Protein GT197
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	256	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 75 (UniProt: P10415)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

A, B, C, D: 76 - 91 (UniProt: Q07817)
A, B, C, D: 92 - 207 (UniProt: P10415)
E, G, F, H: 105 - 130 (UniProt: Q14457)

PDB	External Database	Details
Asp 108	Thr 108	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	89443.5
All*	Total formula weight	89443.5

*Water molecules are not included.