5VAA
Crystal structure of mouse IgG2a Fc T370K mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-2A chain C region, A allele | polymer | 226 | 25614.2 | 2 | UniProt (P01863) Pfam (PF07654) | Mus musculus (Mouse) | Immunoglobulin heavy chain gamma polypeptide |
| 2 | C, D (C, D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 2 | In PDB GlyTouCan (G27919IH) | |||
| 3 | E, G, H (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F, I (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 341 | Chemie (HOH) |
Sequence modifications
A, B: 224 - 447 (UniProt: P01863)
| PDB | External Database | Details |
|---|---|---|
| Gly 222 | - | expression tag |
| Ser 223 | - | expression tag |
| Lys 370 | Thr 253 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51228.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3251.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 666.8 | |
| All* | Total formula weight | 55146.2 |
