5V9I
Crystal structure of catalytic domain of G9a with MS0105
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase EHMT2 | polymer | 283 | 32604.9 | 4 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | AA, BA, CA, E, F... (C, A, D, B) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 3 | DA, I, LA, S (C, A, D, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
| 4 | EA, J, MA, T (C, A, D, B) | N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine | non-polymer | 427.6 | 4 | Chemie (90P) | |||
| 5 | FA, K, L, M, NA... (C, A, D, B) | GLYCEROL | non-polymer | 92.1 | 9 | Chemie (GOL) | |||
| 6 | GA, N, X, Y (C, A, B) | UNKNOWN ATOM OR ION | non-polymer | 4 | Chemie (UNX) | ||||
| 7 | PA, QA, RA, SA (A, B, C, D) | water | water | 18.0 | 700 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 913 - 1193 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 911 | - | expression tag |
| Ser 912 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130419.7 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 5179.5 | |
| All* | Total formula weight | 135599.2 |
