Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5V9I

Crystal structure of catalytic domain of G9a with MS0105

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
B	0002039	molecular_function	p53 binding
B	0005634	cellular_component	nucleus
B	0008270	molecular_function	zinc ion binding
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0042054	molecular_function	histone methyltransferase activity
C	0002039	molecular_function	p53 binding
C	0005634	cellular_component	nucleus
C	0008270	molecular_function	zinc ion binding
C	0016279	molecular_function	protein-lysine N-methyltransferase activity
C	0042054	molecular_function	histone methyltransferase activity
D	0002039	molecular_function	p53 binding
D	0005634	cellular_component	nucleus
D	0008270	molecular_function	zinc ion binding
D	0016279	molecular_function	protein-lysine N-methyltransferase activity
D	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1501

Chain	Residue
A	CYS974
A	CYS987
A	CYS1017
A	CYS1021

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1502

Chain	Residue
A	CYS980
A	CYS1017
A	CYS1023
A	CYS1027

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1503

Chain	Residue
A	CYS976
A	CYS980
A	CYS985
A	CYS974

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1504

Chain	Residue
A	CYS1115
A	CYS1168
A	CYS1170
A	CYS1175

site_id	AC5
Number of Residues	18
Details	binding site for residue SAM A 1505

Chain	Residue
A	MET1048
A	TRP1050
A	SER1084
A	TYR1085
A	ARG1109
A	PHE1110
A	ASN1112
A	HIS1113
A	TYR1154
A	PHE1158
A	PHE1166
A	THR1167
A	CYS1168
A	GLN1169
A	HOH1610
A	HOH1663
A	HOH1696
A	HOH1706

site_id	AC6
Number of Residues	12
Details	binding site for residue 90P A 1506

Chain	Residue
A	ASP1074
A	ALA1077
A	ASP1078
A	ARG1080
A	ASP1083
A	LEU1086
A	ASP1088
A	CYS1098
A	ARG1157
A	PHE1158
A	LYS1162
A	GOL1509

site_id	AC7
Number of Residues	12
Details	binding site for residue GOL A 1507

Chain	Residue
A	GLU931
A	VAL1032
A	GLY1035
A	ILE1036
A	PHE1063
A	CYS1065
A	GLU1066
A	ASN1106
A	HOH1601
A	HOH1613
A	HOH1623
A	HOH1674

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL A 1508

Chain	Residue
A	ILE921
A	PRO936
A	VAL938
A	GLN1041

site_id	AC9
Number of Residues	10
Details	binding site for residue GOL A 1509

Chain	Residue
A	LEU1086
A	PHE1087
A	ASP1088
A	PHE1152
A	ASP1153
A	TYR1154
A	90P1506
A	HOH1603
A	HOH1632
A	HOH1723

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 1501

Chain	Residue
B	CYS974
B	CYS987
B	CYS1017
B	CYS1021

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN B 1502

Chain	Residue
B	CYS980
B	CYS1017
B	CYS1023
B	CYS1027

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN B 1503

Chain	Residue
B	CYS974
B	CYS976
B	CYS980
B	CYS985

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN B 1504

Chain	Residue
B	CYS1115
B	CYS1168
B	CYS1170
B	CYS1175

site_id	AD5
Number of Residues	19
Details	binding site for residue SAM B 1505

Chain	Residue
B	PHE1166
B	THR1167
B	CYS1168
B	GLN1169
B	HOH1608
B	HOH1649
B	HOH1735
B	HOH1756
B	MET1048
B	TRP1050
B	SER1084
B	TYR1085
B	ARG1109
B	PHE1110
B	ILE1111
B	ASN1112
B	HIS1113
B	TYR1154
B	PHE1158

site_id	AD6
Number of Residues	11
Details	binding site for residue 90P B 1506

Chain	Residue
B	ASP1074
B	ALA1077
B	ASP1078
B	ARG1080
B	ASP1083
B	LEU1086
B	ASP1088
B	CYS1098
B	ARG1157
B	PHE1158
B	HOH1715

site_id	AD7
Number of Residues	9
Details	binding site for residue GOL B 1507

Chain	Residue
B	VAL1032
B	GLY1035
B	ILE1036
B	PHE1063
B	GLU1066
B	ASN1106
B	HOH1604
B	HOH1638
B	HOH1648

site_id	AD8
Number of Residues	8
Details	binding site for residue GOL B 1508

Chain	Residue
B	ASP942
B	ARG1044
B	THR1045
B	ALA1046
B	LYS1047
B	MET1048
B	GLY1049
B	HOH1657

site_id	AD9
Number of Residues	7
Details	binding site for residue GOL B 1509

Chain	Residue
B	ASN956
B	LEU1071
B	HIS1128
B	PHE1133
B	PRO1134
B	ARG1135
B	HOH1623

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN C 1501

Chain	Residue
C	CYS974
C	CYS987
C	CYS1017
C	CYS1021

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN C 1502

Chain	Residue
C	CYS980
C	CYS1017
C	CYS1023
C	CYS1027

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN C 1503

Chain	Residue
C	CYS974
C	CYS976
C	CYS980
C	CYS985

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN C 1504

Chain	Residue
C	CYS1115
C	CYS1168
C	CYS1170
C	CYS1175

site_id	AE5
Number of Residues	19
Details	binding site for residue SAM C 1505

Chain	Residue
C	MET1048
C	TRP1050
C	SER1084
C	TYR1085
C	ARG1109
C	PHE1110
C	ILE1111
C	ASN1112
C	HIS1113
C	TYR1154
C	PHE1158
C	PHE1166
C	CYS1168
C	GLN1169
C	HOH1613
C	HOH1618
C	HOH1627
C	HOH1670
C	HOH1740

site_id	AE6
Number of Residues	10
Details	binding site for residue 90P C 1506

Chain	Residue
C	ASP1074
C	ALA1077
C	ASP1078
C	ARG1080
C	ASP1083
C	LEU1086
C	ASP1088
C	CYS1098
C	ARG1157
C	PHE1158

site_id	AE7
Number of Residues	11
Details	binding site for residue GOL C 1507

Chain	Residue
C	VAL1032
C	GLY1035
C	ILE1036
C	PHE1063
C	CYS1065
C	GLU1066
C	ASN1106
C	ARG1135
C	HOH1642
C	HOH1649
C	HOH1658

site_id	AE8
Number of Residues	4
Details	binding site for residue ZN D 1501

Chain	Residue
D	CYS974
D	CYS987
D	CYS1017
D	CYS1021

site_id	AE9
Number of Residues	4
Details	binding site for residue ZN D 1502

Chain	Residue
D	CYS980
D	CYS1017
D	CYS1023
D	CYS1027

site_id	AF1
Number of Residues	4
Details	binding site for residue ZN D 1503

Chain	Residue
D	CYS974
D	CYS976
D	CYS980
D	CYS985

site_id	AF2
Number of Residues	4
Details	binding site for residue ZN D 1504

Chain	Residue
D	CYS1115
D	CYS1168
D	CYS1170
D	CYS1175

site_id	AF3
Number of Residues	19
Details	binding site for residue SAM D 1505

Chain	Residue
D	MET1048
D	TRP1050
D	SER1084
D	TYR1085
D	ARG1109
D	PHE1110
D	ASN1112
D	HIS1113
D	TYR1154
D	PHE1158
D	PHE1166
D	CYS1168
D	GLN1169
D	HOH1617
D	HOH1618
D	HOH1692
D	HOH1696
D	HOH1704
D	HOH1734

site_id	AF4
Number of Residues	11
Details	binding site for residue 90P D 1506

Chain	Residue
D	ASP1074
D	ALA1077
D	ASP1078
D	ARG1080
D	ASP1083
D	LEU1086
D	ASP1088
D	CYS1098
D	ARG1157
D	PHE1158
D	LYS1162

site_id	AF5
Number of Residues	7
Details	binding site for residue GOL D 1507

Chain	Residue
C	TRP1024
D	ASP925
D	GLY929
D	GLU931
D	ASN932
D	VAL933
D	PRO934

site_id	AF6
Number of Residues	6
Details	binding site for residue GOL D 1508

Chain	Residue
D	ASP942
D	THR1045
D	ALA1046
D	MET1048
D	GLY1049
D	HOH1711

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	64
Details	Domain: {"description":"Post-SET"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	72
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)